Evidence map›Paper›PMID 36815771›Full record

ArticleJournal of virology2023

Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome.

Yi Tan, Meghan H Shilts, Christian Rosas-Salazar, Vinita Puri, Nadia Fedorova, Rebecca A Halpin, Siyuan Ma, Larry J Anderson, R Stokes Peebles, Tina V Hartert and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Estrogen and viral infection.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yi Tan *Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Meghan H Shilts *Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Christian Rosas-SalazarDivision of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Vinita PuriDivision of Infectious Diseases, J. Craig Venter Institute, Rockville, Maryland, USA.
Nadia FedorovaDivision of Infectious Diseases, J. Craig Venter Institute, Rockville, Maryland, USA.
Rebecca A HalpinDivision of Infectious Diseases, J. Craig Venter Institute, Rockville, Maryland, USA.
Siyuan MaDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Larry J AndersonDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-0652-6834
R Stokes PeeblesDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Tina V HartertDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-7470-1166
Suman R DasDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-2496-9724
Vanderbilt University Medical Center · USJ. Craig Venter Institute · USVanderbilt University · USEmory University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tina V Hartert · 2011 to 2026
$34.9M
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI NELSON, KAREN E., NIERMAN, WILLIAM CHARLES · 2014 to 2018
$29.7M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
VANTAGE:Consolidation to create the Vanderbilt Technologies for Advanced GenomicsG20RR030956 · NCRR · VANDERBILT UNIVERSITY · PI PIETENPOL, JENNIFER A · 2010 to 2010
$8.7M
Regulation and Function of Polarity and Asymmetric Cell Division in ImmunityR01AI095277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, JOHN T · 2012 to 2016
$2.6M
Molecular Interrogation of the Host-Pathogen Interface in Idiopathic Subglottic StensosisR01HL146401 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GELBARD, ALEXANDER · 2019 to 2023
$1.9M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) TL1TL1RR024978 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$1.3M
The effect of early-life nasal colonization with Lactobacillus on the development of the local immune response and the later onset of recurrent wheeze, childhood asthma, and allergic rhinitisK23HL148638 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROSAS-SALAZAR, CHRISTIAN · 2019 to 2023
$909k
Elucidating the role of nasopharyngeal microbiome in Respiratory Syncytial Virus associated diseases in childrenR21AI149262 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAS, SUMAN RANJAN · 2020 to 2021
$468k
Establishing the role of the upper airway mycobiome on childhood respiratory outcomesR21AI154016 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAS, SUMAN RANJAN, ROSAS-SALAZAR, CHRISTIAN · 2020 to 2021
$468k
NCI NIH HHS P30 CA068485NCRR NIH HHS G20 RR030956NCRR NIH HHS TL1 RR024978NCRR NIH HHS UL1 RR024975NEI NIH HHS P30 EY008126NHLBI NIH HHS K23 HL148638NHLBI NIH HHS R01 HL146401NIAID NIH HHS R01 AI095277NIAID NIH HHS R21 AI149262NIAID NIH HHS R21 AI154016NIAID NIH HHS U19 AI095227NIAID NIH HHS U19 AI110819
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) has a significant health burden in children, older adults, and the immunocompromised. However, limited effort has been made to identify emergence of new RSV genotypes' frequency of infection and how the combination of nasopharyngeal microbiome and viral genotypes impact RSV disease outcomes. In an observational cohort designed to capture the first infant RSV infection, we employed multi-omics approaches to sequence 349 RSV complete genomes and matched nasopharyngeal microbiomes, during which the 2012/2013 season was dominated by RSV-A, whereas 2013 and 2014 was dominated by RSV-B. We found non-G-72nt-duplicated RSV-A strains were more frequent in male infants (

Indexed as

Host Microbial InteractionsMicrobiotaNasopharynxRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsFemaleGenotypeHumansInfantMaleSex Factorsgenotypesincidenceinfantsmicrobiomenext-generation sequencingNGSphylogenyRSVsex difference

Identifiers

PMID36815771
PMCPMC10062153
OpenAlexW4321610855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.