Evidence map›Paper›PMID 36815760›Full record

ArticleAnalytical chemistry2023

Analysis of a Broad Range of Carbonyl Metabolites in Exhaled Breath by UHPLC-MS.

Zhenzhen Xie, James D Morris, Stephanie J Mattingly, Saurin R Sutaria, Jiapeng Huang, Michael H Nantz, Xiao-An Fu

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhenzhen Xie
James D Morris
Stephanie J Mattingly
Saurin R Sutaria
Jiapeng Huang
University of Louisville · US

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
A Handheld Microchip for GC analysis of breath to screen for COVID-19U18TR003787 · NCATS · UNIVERSITY OF LOUISVILLE · PI FU, XIAO-AN, NANTZ, MICHAEL H · 2021 to 2022
$2.0M
A microreactor chip platform for quantitative analysis of unsaturated aldehydes in exhaled breathR21CA229057 · NCI · UNIVERSITY OF LOUISVILLE · PI FU, XIAO-AN · 2018 to 2020
$596k
NCATS NIH HHS U18 TR003787NCI NIH HHS R21 CA229057NIEHS NIH HHS P30 ES030283
6 · The paper itself

Abstract

Analysis of volatile organic compounds (VOCs) in exhaled breath (EB) has shown great potential for disease detection including lung cancer, infectious respiratory diseases, and chronic obstructive pulmonary disease. Although many breath sample collection and analytical methods have been developed for breath analysis, analysis of metabolic VOCs in exhaled breath is still a challenge for clinical application. Many carbonyl compounds in exhaled breath are related to the metabolic processes of diseases. This work reports a method of ultrahigh-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-MS) for the analysis of a broad range of carbonyl metabolites in exhaled breath. Carbonyl compounds in the exhaled breath were captured by a fabricated silicon microreactor with a micropillar array coated with 2-(aminooxy)ethyl-

Indexed as

SiliconVolatile Organic CompoundsAldehydesBreath TestsChromatography, High Pressure LiquidKetonesAldehydesKetonesSiliconVolatile Organic Compounds

Identifiers

PMID36815760
PMCPMC10521381
OpenAlexW4321611348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.