ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Examining the Impact of Socioeconomic Position Across the Life Course on Cognitive Function and Brain Structure in Healthy Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Comprehensive social determinants of health and brain health in midlife.The journal of prevention of Alzheimer's disease · 2026Article
- Contribution of Life-Course Socioeconomic Position to Later-Life Brain Volumes in US Hispanic/Latino Adults.Neurology · 2026Article
- Life-course socioeconomic trajectories and cognitive aging in Chinese middle-aged and older adults.Innovation in aging · 2026Article
- Associations of life course social determinants of health, social mobility with cognitive function and roles of social participation and lifestyle: a multicohort study.BMC medicine · 2025Article
- Edentulism, social mobility, and cognitive aging: a life course perspective.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
- Intergenerational upward educational mobility and cognitive performance: results from the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas.Nature aging · 2025Article
- Cortical Surface Area Profile Mediates Effects of Childhood Disadvantage on Later-Life General Cognitive Ability.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936.Molecular psychiatry · 2024Article
- Association of psychosocial state with subsequent risk of dementia: a prospective cohort study based on the UK Biobank.Alzheimer's research & therapy · 2024Article
- Influence of intergenerational social mobility on brain structure and global cognition: findings from the Whitehall II study across 20 years.Age and ageing · 2024Article
- Structural inequality and temporal brain dynamics across diverse samples.Clinical and translational medicine · 2024Article
- The interactive effects of psychosocial stress and diet composition on health in primates.Neuroscience and biobehavioral reviews · 2023Review
- Neurobiology of Aging: New Insights From Across the Research Spectrum.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Air pollution, dementia, and lifespan in the socio-economic gradient of aging: perspective on human aging for planning future experimental studies.Frontiers in aging · 2023Article
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7 authors.
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Abstract
This study explores the relationship of life-course intergenerational social mobility with cognitive function and brain structure in older adults using Diagonal Reference Models. Data from the Irish Longitudinal Study on Ageing, a population-based cohort of adults aged 50 years and older (N = 4 620 participants; mean age: 66.1; standard deviation: 9.1; 55% female) was used for analysis. Brain magnetic resonance imaging data were available for 464 participants. Social mobility was characterized as the difference between childhood socioeconomic position (SEP; ie, father's occupation) and adulthood SEP (ie, own occupation). The Montreal Cognitive Assessment (MoCA), the Mini-Mental State Examination (MMSE), cortical thickness, and total gray matter volume (GMV) served as global cognitive and brain measures. Exploratory analyses included the volumes of the ventromedial prefrontal cortex (vmPFC), anterior cingulate (AC), hippocampus, and amygdala. A social gradient in cognitive function was observed among the intergenerationally stable; brain structure was not as clearly socially patterned. Adulthood SEP was significantly associated with MoCA (weight = 0.76; p < .001), MMSE (weight = 0.91; p < .001), GMV (weight = 0.77; p = .002), and AC volume (weight = 0.76; p < .001), whereas childhood SEP was associated with vmPFC volume (weight = 1.00; p = .003). There was no independent association of social mobility with any of the outcomes. Together our results suggest that both childhood and adulthood SEP are important in shaping later-life brain health, but that adulthood SEP predominates in terms of its influence. This is potentially an important insight as it suggests that brain health may be modifiable if socioeconomic circumstances change.
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