Evidence map›Paper›PMID 36815512›Full record

ArticleJournal of clinical research in pediatric endocrinology2025

Diagnostic Pitfalls of a Newborn with Congenital Nephrogenic Diabetes Insipidus

Ömer Güran, Serçin Güven, Heves Kırmızıbekmez, Özlem Akgün Doğan, Leyla Karadeniz Bilgin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ömer GüranUniversity of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Clinic of Neonatology, İstanbul, TürkiyeORCID 0000-0002-5146-6949
Serçin GüvenUniversity of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Clinic of Paediatric Nephrology, İstanbul, TürkiyeORCID 0000-0003-3284-9204
Heves KırmızıbekmezUniversity of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Clinic of Paediatric Endocrinology and Diabetes, İstanbul, TürkiyeORCID 0000-0002-8663-3452
Özlem Akgün DoğanUniversity of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Clinic of Paediatric Genetics, İstanbul, TürkiyeORCID 0000-0002-8310-4053
Leyla Karadeniz BilginUniversity of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Clinic of Neonatology, İstanbul, TürkiyeORCID 0000-0003-4035-1713
Sağlık Bilimleri Üniversitesi · TRUniversity of Health Sciences Antigua · AG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital nephrogenic diabetes insipidus (NDI) is a rare cause of hypernatremia in newborns. Central diabetes insipidus (CDI) is the main differential diagnosis in NDI, however NDI responds poorly to desmopressin acetate (DDAVP) treatment, while this is the mainstay of CDI management. Therefore, early and correct diagnosis of NDI is important to avoid the complications of inappropriate therapy. We report a newborn with hypernatremia and hypotonic polyuria. The patient was initially responsive but subsequently unresponsive to intranasal DDAVP treatment in terms of both urine output and serum sodium levels. A novel hemizygous missense mutation (c.632T>C, p.L211P) in the

Indexed as

Diabetes Insipidus, NephrogenicDeamino Arginine VasopressinDiagnosis, DifferentialHumansHypernatremiaInfant, NewbornMaleMutation, MissenseReceptors, VasopressinAVPR2 protein, humanDeamino Arginine VasopressinReceptors, VasopressinAVPR2hypernatremianeonateNephrogenic diabetes insipidus

Identifiers

PMID36815512
PMCPMC11923502
OpenAlexW4321596173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.