Evidence map›Paper›PMID 36815385›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Immunogenic Cell Death in Hematological Malignancy Therapy.

Zhaoyun Liu, Xintong Xu, Kaining Liu, Jingtian Zhang, Dan Ding, Rong Fu

Open access · goldAbstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 58 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhaoyun LiuDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
Xintong XuDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
Kaining LiuState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive, Materials, Ministry of Education and College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China.
Jingtian ZhangState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive, Materials, Ministry of Education and College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China.
Dan DingState Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive, Materials, Ministry of Education and College of Life Sciences, Nankai University, Tianjin, 300071, P. R. China.ORCID 0000-0003-1873-6510
Rong FuDepartment of Hematology, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
Nankai University · CNTianjin Medical University General Hospital · CN

Funding

Medjaden Academy and Research Foundation for Young Scientists MJR20221011National Natural Science Foundation of China 81900131National Natural Science Foundation of China 82000219National Natural Science Foundation of China Youth Project 8210010129Tianjin Education Commission Research Project 20140118Tianjin Education Commission Research Project 2018KJ043Tianjin Education Commission Research Project 2018KJ045Tianjin Key Medical Discipline (Specialty) Construction project TJYXZDXK-028ATianjin Municipal Health Commission Youth Project TJWJ2021QN001Tianjin Municipal Natural Science Foundation 18JCQNJC80400Tianjin Municipal Natural Science Foundation 19JCZDJC32900Tianjin Science and Technology Planning Project 20YFZCSY00060
6 · The paper itself

Abstract

Although the curative effect of hematological malignancies has been improved in recent years, relapse or drug resistance of hematological malignancies will eventually recur. Furthermore, the microenvironment disorder is an important mechanism in the pathogenesis of hematological malignancies. Immunogenic cell death (ICD) is a unique mechanism of regulated cell death (RCD) that triggers an intact antigen-specific adaptive immune response by firing a set of danger signals or damage-associated molecular patterns (DAMPs), which is an immunotherapeutic modality with the potential for the treatment of hematological malignancies. This review summarizes the existing knowledge about the induction of ICD in hematological malignancies and the current research on combining ICD inducers with other treatment strategies for hematological malignancies.

Indexed as

Antineoplastic AgentsHematologic NeoplasmsNeoplasmsEndoplasmic Reticulum StressHumansImmunogenic Cell DeathTumor MicroenvironmentAntineoplastic Agentsaggregation-induced emissionimmunogenic cell deathmultiple myelomaphotodynamic therapyreactive oxygen species

Identifiers

PMID36815385
PMCPMC10161053
OpenAlexW4321598342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.