Evidence map›Paper›PMID 36815184›Full record

ArticleJournal of diabetes research2023

Epigenetic Changes Induced by High Glucose in Human Pancreatic Beta Cells.

Rasha A Alhazzaa, Raechel E McKinley, Bruk Getachew, Yousef Tizabi, Thomas Heinbockel, Antonei B Csoka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Rasha A AlhazzaaDepartment of Anatomy, Howard University, 520 W St. NW, Washington DC 20059, USA.ORCID https://orcid.org/0000-0003-4346-2646
Raechel E McKinleyDepartment of Anatomy, Howard University, 520 W St. NW, Washington DC 20059, USA.
Bruk GetachewDepartment of Pharmacology, Howard University, 520 W St. NW, Washington DC 20059, USA.ORCID https://orcid.org/0000-0003-3523-2154
Yousef TizabiDepartment of Pharmacology, Howard University, 520 W St. NW, Washington DC 20059, USA.ORCID https://orcid.org/0000-0003-1703-1842
Thomas HeinbockelDepartment of Anatomy, Howard University, 520 W St. NW, Washington DC 20059, USA.ORCID https://orcid.org/0000-0003-4347-2131
Antonei B CsokaDepartment of Anatomy, Howard University, 520 W St. NW, Washington DC 20059, USA.ORCID https://orcid.org/0000-0002-7287-5856
Howard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic changes in pancreatic beta cells caused by sustained high blood glucose levels, as seen in prediabetic conditions, may contribute to the etiology of diabetes. To delineate a direct cause and effect relationship between high glucose and epigenetic changes, we cultured human pancreatic beta cells derived from induced pluripotent stem cells and treated them with either high or low glucose, for 14 days. We then used the Arraystar 4x180K HG19 RefSeq Promoter Array to perform whole-genome DNA methylation analysis. A total of 478 gene promoters, out of a total of 23,148 present on the array (2.06%), showed substantial differences in methylation (

Indexed as

Insulin-Secreting CellsDNA MethylationEpigenesis, GeneticGlucoseHumansInsulin SecretionGlucose

Identifiers

PMID36815184
PMCPMC9940985
OpenAlexW4320484493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.