ArticleClinical epidemiology2023
The Metabolic Score for Insulin Resistance (METS-IR) Predicts Cardiovascular Disease and Its Subtypes in Patients with Hypertension and Obstructive Sleep Apnea.
Article in Clinical epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Metabolic score for insulin resistance and the incidence of cardiovascular disease: a meta-analysis of cohort studies.Frontiers in endocrinology · 2025Pooled it
- Association of Metabolic Score for Insulin Resistance with Intraoperative QTc Interval Changes During Laparoscopic Sleeve Gastrectomy: A Prospective Observational Study.Obesity surgery · 2026Observational
- Head-to-head comparison of fasting-insulin-based versus non-insulin-based insulin resistance surrogates for predicting all-cause and cardiovascular mortality in hypertensive adults across the glycemic continuum: a prospective cohort study.Cardiovascular diabetology · 2026Article
- The role of visceral obesity surrogate markers in predicting cardiovascular disease: Insights from the CHARLS study.Medicine · 2026Article
- From Metabolism to Mind: The Cardio-Metabolic-Brain Axis and the Role of Insulin Resistance-A Review.Biomedicines · 2026Review
- Insulin-resistance indices and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome stage 2: a comparative analysis of eGDR, TyG and METS-IR.Diabetology & metabolic syndrome · 2026Article
- Article
- The Prognostic Value of Insulin Resistance Indices for Major Adverse Cardiovascular Events in Young and Middle-Aged Patients With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- METS-IR predicts new-onset stroke in older adults with stages 0-3 cardiovascular-kidney-metabolic syndrome: a prospective, multicohort, clinical study with statistical and machine learning.Diabetology & metabolic syndrome · 2025Article
- Comparative analysis of insulin resistance indicators in predicting reversion from prediabetes to normoglycemia.Diabetology & metabolic syndrome · 2025Article
- Associations between six cumulative insulin resistance-related indices and incident stroke in individuals with different glucose regulation statuses: a national cohort study in China.Lipids in health and disease · 2025Article
- Acute Coronary Syndrome in Intensive Care Unit Patients: Troponin or Triglyceride Glucose Index Levels?Journal of clinical medicine · 2025Article
- Neck circumference predicts the incident cardiac events of obese hypertension with obstructive sleep apnea.American journal of preventive cardiology · 2025Article
- Association between the metabolic score for insulin resistance trajectory and new-onset metabolic syndrome: a retrospective cohort study based on health check-up data in China.Lipids in health and disease · 2025Article
- Estimated glucose disposal rate and risk of cardiovascular events in type 1 diabetes: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2025Review
- Association between metabolic score for insulin resistance and hypertension in middle-aged and older adults: a nationwide cross-sectional and longitudinal study.Aging clinical and experimental research · 2025Article
- The association of the non-HDL-cholesterol to HDL-cholesterol ratio (NHHR) with obstructive sleep apnea among adults aged ≥ 40 years: results from NHANES 2015-2018.BMC public health · 2025Article
- The use of statins are associated with an increased risk of new-onset diabetes in patients with hypertension and obstructive sleep apnoea, a longitudinal study.Diabetology & metabolic syndrome · 2025Article
- Associations between triglyceride-glucose index combined with waist circumference and heart failure in individuals with different body mass indices: a cross-sectional study using NHANES 2011-2020 data.Lipids in health and disease · 2025Article
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007-2018.Lipids in health and disease · 2025Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: We aimed to evaluate the METS-IR (metabolic score for insulin resistance) index for the prediction of incident cardiovascular disease (CVD) and its subtypes (coronary artery disease and stroke) in patients with hypertension and obstructive sleep apnea (OSA). Methods: A retrospective cohort study was conducted with 2031 adults with hypertension and OSA, participants from the Urumqi Research on Sleep Apnea and Hypertension study (UROSAH). The hazard ratios and 95% CIs (credibility interval) for CVD and its subtypes were estimated using multivariate Cox proportional hazards regression models. Results: After a median follow-up of 6.80 years (interquartile range: 5.90-8.00 years), a total of 317 (15.61%) participants developed new-onset CVD, including 198 (9.75%) incident coronary heart disease (CHD) and 119 (5.86%) incident stroke. After adjusting for as many relevant confounding factors as possible, each SD increase in METS-IR was associated with a 30% increased risk of new onset overall CVD events, a 32% increased risk of new onset CHD, and a 27% increased risk of new onset stroke. When METS-IR was assessed as tertiles, after adjustment for fully confounding factors, the highest tertiles versus the lowest tertiles were associated with a greater hazard of CVD (HR 2.05; 95% CI 1.52,-2.77), CHD (HR 1.96; 95% CI 1.35-2.84), and stroke (HR 2.24; 95% CI 1.35-3.72). The results of various subgroups and sensitivity analyses were similar. When METS-IR was added, CVD predictions were reclassified and identified more accurately than baseline models for the C-index, continuous net reclassification improvement, and integrated discrimination index. CHD and stroke showed similar results. Conclusion: METS-IR is a powerful predictor of CVD and its subtypes in patients with hypertension and OSA, which can facilitate the identification of high-risk individuals and provide individualized CVD prevention.
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