Evidence map›Paper›PMID 36815120›Full record

ArticleKidney international reports2023

Scope and Consistency of Cancer Outcomes Reported in Randomized Trials in Kidney Transplant Recipients.

Eric H Au, Germaine Wong, Allison Tong, Armando Teixeira-Pinto, Anita van Zwieten, Ellen Dobrijevic, Curie Ahn, Christopher D Blosser, Bianca Davidson, Anna Francis and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 6 countries.

Eric H AuSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Germaine WongSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Allison TongSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Armando Teixeira-PintoSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Anita van ZwietenSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Ellen DobrijevicSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Curie AhnDivision of Nephrology, National Medical Center, Seoul, Korea.
Christopher D BlosserDivision of Nephrology, Department of Medicine, University of Washington School of Medicine, and Division of Nephrology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.
Bianca DavidsonDivision of Nephrology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Anna FrancisQueensland Children's Hospital, Queensland, Australia.
Kenar D JhaveriDivision of Kidney Diseases and Hypertension, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA.
Jolanta MalyszkoDepartment of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
Alejandra Mena-GutierrezWake Forest School of Medicine, Winston-Salem, North Carolina, United States.
Kenneth A NewellDepartment of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Sarah PalmerSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Nicole Scholes-RobertsonSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Helio Tedesco Silva JuniorFederal University of Sao Paulo, Sao Paulo, Brazil.
Jonathan C CraigCollege of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
The University of Sydney · AUChildren's Hospital at Westmead · AUDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USEmory University · USFlinders University · AUMedical University of Warsaw · PLNational Medical Center · KRQueensland Children’s Hospital · AUSeattle Children's Hospital · USUniversidade Federal de São Paulo · BRUniversity of Cape Town · ZAWake Forest University · USWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cancer is an important outcome in kidney transplantation, but the scope and consistency of how cancer is defined and reported in trials involving kidney transplant recipients has not been evaluated. This study aimed to assess the range and variability of cancer outcomes in trials involving kidney transplant recipients. Methods: The ClinicalTrials.gov database was searched from February 2000 to July 2021 to identify all randomized controlled trials (RCTs) in adult kidney transplant recipients, and which included cancer as a specified outcome. The definition of cancer, types of cancer (if any), timepoint(s) of measurement and method of aggregation were extracted for each cancer outcome. Results: Of the 819 trials in kidney transplantation, only 84 (10%) included 1 or more cancer outcomes. Of these, 72 of 84 (86%) trials included cancer as a secondary outcome and 12 of 84 (14%) considered cancer as a primary outcome. The most frequent description of cancer was "malignancy" ( Conclusion: Cancer is an infrequently reported outcome and is inconsistently defined in trials of kidney transplant recipients. Consistent reporting of cancer outcomes using standardized definitions would provide important information on the impact of cancer in patients after kidney transplantation.

Indexed as

cancerkidney transplantoutcomesrandomized controlled trials

Identifiers

PMID36815120
PMCPMC9939355
OpenAlexW4308905273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.