Evidence map›Paper›PMID 36815108›Full record

ArticleKidney international reports2023

High Macrophage Densities in Native Kidney Biopsies Correlate With Renal Dysfunction and Promote ESRD.

Maren B Pfenning, Jessica Schmitz, Irina Scheffner, Kevin Schulte, Abedalrazag Khalifa, Hossein Tezval, Alexander Weidemann, Anke Kulschewski, Ulrich Kunzendorf, Sebastian Dietrich and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Monocytes and Macrophages in Kidney Disease and Homeostasis.International journal of molecular sciences · 2024
    Review
  8. Targeting inerleukin-6 for renoprotection.Frontiers in immunology · 2024
    Review
  9. Renal MRI: From Nephron to NMR Signal.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  10. Article
  11. Macrophages-Stealth Cells Below the Radar.Kidney international reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Maren B PfenningNephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Jessica SchmitzNephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Irina ScheffnerClinic for Kidney and Hypertension Diseases, Hannover Medical School, Hannover, Lower Saxony, Germany.
Kevin SchulteClinic for Nephrology and Hypertension, Christian-Albrechts-University, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Schleswig-Holstein, Germany.
Abedalrazag KhalifaNephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Hossein TezvalDepartment of Urology and Urological Oncology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Alexander WeidemannMedical Clinic III - Nephrology and Dialysis, St. Vinzenz Hospital, Paderborn, North Rhine-Westphalia, Germany.
Anke KulschewskiClinic for Nephrology and Hypertension, University Hospital Oldenburg, Oldenburg, Lower Saxony, Germany.
Ulrich KunzendorfClinic for Nephrology and Hypertension, Christian-Albrechts-University, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Schleswig-Holstein, Germany.
Sebastian DietrichClinic for Nephrology and Hypertension, Christian-Albrechts-University, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Schleswig-Holstein, Germany.
Hermann HallerClinic for Kidney and Hypertension Diseases, Hannover Medical School, Hannover, Lower Saxony, Germany.
Jan T KielsteinMedical Clinic V, Nephrology, Rheumatology and Blood Purification, Academic Teaching Hospital Braunschweig, Braunschweig, Lower Saxony, Germany.
Wilfried GwinnerClinic for Kidney and Hypertension Diseases, Hannover Medical School, Hannover, Lower Saxony, Germany.
Jan H BräsenNephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Lower Saxony, Germany.
Medizinische Hochschule Hannover · DEUniversity of Lübeck · DEKlinikum Braunschweig · DEKlinikum Oldenburg · DEKlinikum Passau · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Macrophages and monocytes are main players in innate immunity. The relevance of mononuclear phagocyte infiltrates on clinical outcomes remains to be determined in native kidney diseases. Methods: Our cross-sectional study included 324 patients with diagnostic renal biopsies comprising 17 disease entities and normal renal tissues for comparison. All samples were stained for CD68 Results: Biopsies with renal disease consistently revealed higher CD68 Conclusion: Precise quantification of macrophage densities in renal biopsies may contribute to risk stratification to identify patients with high risk for end-stage renal disease (ESRD) and might be a promising therapeutic target in renal disease.

Indexed as

Dialysis riskDigital pathologyDisease progressionMacrophageNative kidney diseaseRenal pathology

Identifiers

PMID36815108
PMCPMC9939427
OpenAlexW4310137332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.