ArticleFrontiers in neurology2023
Prognostic value of inflammation biomarkers for 30-day mortality in critically ill patients with stroke.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- A systematic review and dose-response meta-analysis of red blood cell distribution width to albumin ratio as mortality predictor in cardiovascular disease.Scientific reports · 2025Pooled it
- Association between neutrophil-to-lymphocyte ratio and functional outcomes in patients with large vessel occlusion stroke treated with endovascular thrombectomy.BMC neurology · 2026Article
- Inflammatory indices as independent predictors of in-hospital mortality in acute upper gastrointestinal bleeding.BMC gastroenterology · 2026Observational
- A retrospective analysis of the link between the prognostic nutritional index and 1-year mortality rates in older adults suffering from femoral neck fractures.Frontiers in nutrition · 2026Article
- Prognostic nutritional index, sarcopenia, and risk of mortality: a national population-based study.Nutrition & metabolism · 2025Article
- Inflammatory Biomarkers and Carotid Atherosclerosis: The Predictive Role of the Neutrophil/Albumin Ratio.Medicina (Kaunas, Lithuania) · 2025Article
- Red cell distribution width-to-albumin ratio and hypertension risk: age-specific threshold effects identified in the 2017-2020 NHANES U.S. Adult population.BMC cardiovascular disorders · 2025Article
- Neutrophil-Percentage-to-Albumin Ratio as a Predictor of Coronary Artery Ectasia: A Comparative Analysis with Inflammatory Biomarkers.Diagnostics (Basel, Switzerland) · 2025Article
- Clinical value of inflammatory indices in predicting poor prognosis and post-hemorrhagic hydrocephalus in patients with intraventricular hemorrhage.BMC neurology · 2025Article
- Neutrophil-to-lymphocyte ratio and systemic inflammation response index as biomarkers for the clinical outcomes of intracerebral hemorrhagic stroke patients: a prospective cohort study.Frontiers in neurology · 2025Article
- Distinct trajectory patterns of neutrophil-to-albumin ratio predict clinical outcomes after endovascular therapy in large vessel occlusion stroke.Frontiers in aging neuroscience · 2025Article
- High platelet-to-albumin ratio is associated with 30-day mortality in critically ill patients.European journal of medical research · 2024Article
- A novel higher performance nomogram based on explainable machine learning for predicting mortality risk in stroke patients within 30 days based on clinical features on the first day ICU admission.BMC medical informatics and decision making · 2024Article
- Relationship Between Systemic Immune-Inflammation Index and Risk of Respiratory Failure and Death in COPD: A Retrospective Cohort Study Based on the MIMIC-IV Database.International journal of chronic obstructive pulmonary disease · 2024Article
- Exploring the utility of a latent variable as comprehensive inflammatory prognostic index in critically ill patients with cerebral infarction.Frontiers in neurology · 2024Article
- Machine learning-based nomogram: integrating MRI radiomics and clinical indicators for prognostic assessment in acute ischemic stroke.Frontiers in neurology · 2024Article
- Neutrophil-to-albumin Ratio as a Prognostic Factor in Patients with Acute Ischemic Stroke.Current neurovascular research · 2024Article
- The lactate-to-albumin ratio relationship with all-cause mortality in cerebral infarction patients: analysis from the MIMIC-IV database.Frontiers in neurology · 2024Article
- Association of prognostic nutritional index with the risk of all-cause mortality and cardiovascular mortality in patients with type 2 diabetes: NHANES 1999-2018.BMJ open diabetes research & care · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To explore the values of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), neutrophil to albumin ratio (NAR), prognostic nutritional index (PNI), systemic immune inflammatory index (SII) and red cell distribution width to albumin ratio (RA) for evaluating the risk of 30-day mortality of ischemic stroke or hemorrhagic stroke patients. Methods: In this cohort study, the data of 1,601 patients diagnosed with stroke were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Among them, 908 were hemorrhagic stroke patients and 693 were ischemic stroke patients. Demographic and clinical variables of patients were collected. Univariate and multivariable Cox regression were performed to evaluate the predictive values of NLR, PLR, SII, NAR, RA, and PNI for 30-day mortality in hemorrhagic stroke or ischemic stroke patients. The receiver operator characteristic (ROC) curves were plotted to assess the predictive values of NLR, NAR, and RA for 30-day mortality of hemorrhagic stroke patients. Results: At the end of follow-up, 226 hemorrhagic stroke patients and 216 ischemic stroke patients died. The elevated NLR level was associated with increased risk of 30-day mortality in hemorrhagic stroke [hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.06-1.29]. The increased NAR level was associated with elevated risk of 30-day mortality in hemorrhagic stroke (HR = 1.16, 95% CI: 1.02-1.30). The high RA level was linked with increased risk of 30-day mortality (HR = 1.44, 95% CI: 1.23-1.69). No significant correlation was observed in these inflammation biomarkers with the risk of 30-day mortality in ischemic stroke patients. The area under the curves (AUCs) of NLR, RA, and NAR for evaluating the risk of 30-day mortality of hemorrhagic stroke patients were 0.552 (95% CI: 0.503-0.601), 0.644 (95% CI: 0.590-0.699) and 0.541 (95% CI: 0.490-0.592). Conclusion: NLR, NAR, and RA were potential prognostic biomarkers for predicting 30-day mortality of hemorrhagic stroke patients, which might provide clinicians an easy and cheap way to quickly identify patients with high risk of mortality.
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