Evidence map›Paper›PMID 36814964›Full record

ReviewCanadian journal of kidney health and disease2023

Magnesium and Fracture Risk in the General Population and Patients Receiving Dialysis: A Narrative Review.

Andrea C Cowan, Kristin K Clemens, Jessica M Sontrop, Stephanie N Dixon, Lauren Killin, Sierra Anderson, Rey R Acedillo, Amit Bagga, Clara Bohm, Pierre Antoine Brown and 23 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Canadian journal of kidney health and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 2 countries.

Andrea C CowanDivision of Nephrology, Department of Medicine, Victoria Hospital, London Health Sciences Centre, ON, Canada.ORCID https://orcid.org/0000-0002-9480-969X
Kristin K ClemensDivision of Endocrinology, Department of Medicine, St. Joseph's Hospital, London, ON, Canada.
Jessica M SontropDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0001-7784-2028
Stephanie N DixonDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada.ORCID https://orcid.org/0000-0002-7566-6574
Lauren KillinICES Western, London, ON, Canada.
Sierra AndersonICES Western, London, ON, Canada.
Rey R AcedilloDepartment of Medicine, Thunder Bay Regional Health Sciences Centre, ON, Canada.
Amit BaggaWindsor Regional Hospital, ON, Canada.
Clara BohmChronic Disease Innovation Centre, Winnipeg, MB, Canada.
Pierre Antoine BrownDepartment of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-0283-4530
Brenden CotePatient Partner, London Health Sciences Centre, ON, Canada.
Varun DevHumber River Hospital, Toronto, ON, Canada.
Claire HarrisDivision of Nephrology, Department of Medicine, Vancouver General Hospital, The University of British Columbia, Canada.
Swapnil HiremathDepartment of Medicine, University of Ottawa, ON, Canada.ORCID https://orcid.org/0000-0003-0010-3416
Mercedeh KiaiiDivision of Nephrology, Department of Medicine, St. Paul's Hospital, Vancouver, BC, Canada.
Eduardo LacsonDivision of Nephrology, Tufts University School of Medicine, Boston, MA, USA.
Amber O MolnarDepartment of Medicine, St Joseph's Healthcare Hamilton, ON, Canada.ORCID https://orcid.org/0000-0003-4549-0202
Matthew J OliverDivision of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
Malvinder S ParmarDepartment of Medicine, Timmins and District Hospital, ON, Canada.ORCID https://orcid.org/0000-0003-3182-0530
Jennifer M McRaeDivision of Nephrology, Department of Medicine, University of Calgary, AB, Canada.
Bharat NathooMackenzie Health, Richmond Hill, ON, Canada.
Kathleen QuinnNiagara Health System, St. Catharines, ON, Canada.
Nikhil ShahUniversity of Alberta, Edmonton, Canada.
Samuel A SilverDivision of Nephrology, Kingston Health Sciences Center, Queen's University, ON, Canada.ORCID https://orcid.org/0000-0002-1843-6131
Daniel J TasconaOrillia Soldiers' Memorial Hospital, ON, Canada.
Stephanie ThompsonDivision of Nephrology, University of Alberta, Edmonton, Canada.ORCID https://orcid.org/0000-0003-3109-6837
Robert H TingUniversity of Toronto, ON, Canada.
Marcello TonelliCumming School of Medicine, University of Calgary, AB, Canada.
Hans VorsterCan-SOLVE CKD Network, Vancouver, BC, Canada.
Davinder B WadehraWilliam Osler Health System, Etobicoke, ON, Canada.
Ron WaldDivision of Nephrology, St. Michael's Hospital, University of Toronto, ON, Canada.
Myles WolfDivision of Nephrology, Department of Medicine, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Amit X GargDivision of Nephrology, Department of Medicine, Victoria Hospital, London Health Sciences Centre, ON, Canada.ORCID https://orcid.org/0000-0003-3398-3114
London Health Sciences Centre · CAUniversity of Alberta · CAUniversity of Calgary · CAUniversity of Ottawa · CAWestern University · CADuke University · USHumber River Regional Hospital · CANiagara Health System · CAOrthopaedic Innovation Centre · CAQueen's University · CASt. Joseph’s Healthcare Hamilton · CASt. Joseph's Hospital · CASt. Michael's Hospital · CASt. Paul's Hospital · CASunnybrook Health Science Centre · CAThunder Bay Regional Health Sciences Centre · CATufts University · USUniversity of British Columbia · CAUniversity of Toronto · CAWilliam Osler Health System · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose of Review: Magnesium is an essential mineral for bone metabolism, but little is known about how magnesium intake alters fracture risk. We conducted a narrative review to better understand how magnesium intake, through supplementation, diet, or altering the concentration of dialysate magnesium, affects mineral bone disease and the risk of fracture in individuals across the spectrum of kidney disease. Sources of Information: Peer-reviewed clinical trials and observational studies. Methods: We searched for relevant articles in MEDLINE and EMBASE databases. The methodologic quality of clinical trials was assessed using a modified version of the Downs and Black criteria checklist. Key Findings: The role of magnesium intake in fracture prevention is unclear in both the general population and in patients receiving maintenance dialysis. In those with normal kidney function, 2 meta-analyses showed higher bone mineral density in those with higher dietary magnesium, whereas 1 systematic review showed no effect on fracture risk. In patients receiving maintenance hemodialysis or peritoneal dialysis, a higher concentration of dialysate magnesium is associated with a lower concentration of parathyroid hormone, but little is known about other bone-related outcomes. In 2 observational studies of patients receiving hemodialysis, a higher concentration of serum magnesium was associated with a lower risk of hip fracture. Limitations: This narrative review included only articles written in English. Observed effects of magnesium intake in the general population may not be applicable to those with chronic kidney disease particularly in those receiving dialysis.

Indexed as

fracturehemodialysismagnesiummineral bone diseaseparathyroid horomone

Identifiers

PMID36814964
PMCPMC9940170
OpenAlexW4321226078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.