Evidence map›Paper›PMID 36814599›Full record

ArticleFrontiers in cell and developmental biology2023

Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification.

Ziadoon Al-Akashi, Denise Zujur, Daisuke Kamiya, Tomohisa Kato, Toru Kondo, Makoto Ikeya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ziadoon Al-AkashiCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Denise ZujurCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Daisuke KamiyaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Tomohisa KatoMedical Research Institute, Kanazawa Medical University, Kanazawa, Japan.
Toru KondoInstitute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Makoto IkeyaCenter for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
Kyoto University · JPHokkaido University · JPKanazawa Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of induced mesenchymal stem/stromal cells (iMSCs) derived from human induced pluripotent stem cells (hiPSCs) in regenerative medicine involves the risk of teratoma formation due to hiPSCs contamination in iMSCs. Therefore, eradicating the remaining undifferentiated hiPSCs is crucial for the effectiveness of the strategy. The present study demonstrates the Brequinar (BRQ)-induced inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme in

Indexed as

brequinar (BRQ)dihydroorotate dehydrogenase (DHODH)induced mesenchymal stromal cells (iMSCs)induced pluripotent stem cells (hiPSC)mesenchymal stem/stromal cells (MSCs)pyrimidine biosynthesissurvival

Identifiers

PMID36814599
PMCPMC9939518
OpenAlexW4319321911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.