ReviewFrontiers in endocrinology2023
Hypothyroidism: The difficulty in attributing symptoms to their underlying cause.
Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Impact of a Mobile Health Application on Medication Adherence, Thyroid Function, and Quality of Life in Patients with Hypothyroidism: A Prospective Comparative Study.Pakistan journal of medical sciences · 2026Article
- The Effect of Progressive Muscle Relaxation Technique on Fatigue and Depression in Patients With Hypothyroidism: A Randomized Controlled Trial.Health science reports · 2026Article
- Alternative and Complementary Therapies: A Review Exploring the Role of Yoga and Ayurveda-based Herbal Medicines in Alleviating Hypothyroidism and Its Neuropsychiatric Manifestations.Annals of neurosciences · 2026Review
- Thyroid Function Testing in Hospitalized Patients: A Practical Framework for Clinicians.Cureus · 2026Review
- Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?Clinical endocrinology · 2026Article
- Psychosis with untreated hypothyroidism: How a generalist made a difference.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2026Article
- The role of hypothyroidism in the resilience against depressive episodes during covid pandemic in a cohort of old adults.Frontiers in psychiatry · 2026Article
- The frequency of regulatory T-cells in Hashimoto's thyroiditis and Graves' disease.Clinical and experimental medicine · 2025Article
- Subtype-specific causal effects of hypothyroidism on obstructive sleep apnea: A bidirectional Mendelian randomization study.Medicine · 2025Article
- The role of interviewing in endocrine practice.Journal of endocrinological investigation · 2025Review
- Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy.Science advances · 2025Article
- Per and polyfluoroalkyl substances affect thyroid hormones for people with a history of exposure from drinking water.Scientific reports · 2025Article
- Self-Management and Support Needs of Patients Experiencing Persistent Symptoms Consistent With Hypothyroidism: A Qualitative Study.Journal of patient-centered research and reviews · 2025Article
- Ultrasound, Doppler and other signs during drug-free transition from subclinical hypothyroidism to euthyroidism: a case report.AME case reports · 2025Article
- Roxadustat has risks of reversible central hypothyroidism in patients undergoing hemodialysis: a single-center retrospective cohort study.Renal failure · 2024Article
- A Real-Life Study in Patients Newly Diagnosed with Autoimmune Hashimoto's Thyroiditis: Analysis of Asthenia as Admission Complaint.Life (Basel, Switzerland) · 2024Article
- Beyond the Thyroid: A Narrative Review of Extra-thyroidal Manifestations in Hashimoto's Disease.Cureus · 2024Review
- Hypothyroidism Presenting Atypically as an Isolated Pericardial and Pleural Effusion: A Case Report.Cureus · 2024Article
- Quality of life, daily functioning, and symptoms in hypothyroid patients on thyroid replacement therapy: A Dutch survey.Journal of clinical & translational endocrinology · 2024Article
- Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common symptoms of overt hypothyroidism are non-specific and include fatigue, lethargy, and dry skin. Although the diagnosis is considered to be straightforward, no single symptom can be used to identify patients with overt hypothyroidism, while many patients with subclinical hypothyroidism are asymptomatic. A large population-based study on the spectrum of symptoms in subclinical hypothyroidism showed similar rates of thyroid disease-related symptoms compared with euthyroid subjects, while the TSH concentration had no impact on symptom score. Together, these findings make it challenging to attribute symptoms to their underlying cause. This is also true in the case of unexplained persistent symptoms in levothyroxine-treated patients. Although generally considered a life-long replacement therapy, successful thyroid hormone discontinuation resulting in euthyroidism has been reported in approximately one third of patients. Thus, we overtreat patients with (subclinical) hypothyroidism, highlighting the importance of reliable diagnostic criteria. The diagnostic process, including the implementation of robust TSH and FT4 reference intervals, is especially challenging in specific situations including aging, pregnancy, non-thyroidal illness, and central hypothyroidism. There is a clear need for improved adherence to current guidelines from scientific societies and for willingness to manage symptoms without a clear pathological correlate, especially in the case of mild TSH elevations. This review will highlight recent literature on this topic and offers some practice points.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.