Evidence map›Paper›PMID 36814474›Full record

ArticleFrontiers in physiology2023

Sodium/(calcium + potassium) exchanger NCKX4 optimizes KLK4 activity in the enamel matrix microenvironment to regulate ECM modeling.

Barry Chan, Ieong Cheng Cheng, Jalali Rozita, Ida Gorshteyn, Yulei Huang, Ida Shaffer, Chih Chang, Wu Li, Jonathan Lytton, Pamela Den Besten and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Barry ChanDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Ieong Cheng ChengDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Jalali RozitaDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Ida GorshteynDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Yulei HuangGuangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun-Yat-sen University, Guangzhou, China.
Ida ShafferDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Chih ChangDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Wu LiDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Jonathan LyttonDepartment of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada.
Pamela Den BestenDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
Yan ZhangDepartment of Orofacial Sciences, University of California, San Francisco, CA, San Francisco, United States.
University of California, San Francisco · USSun Yat-sen University · CNUniversity of Calgary · CA

Funding

Enamel biomineralization; the role of pH cyclingR01DE027971 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pamela K Den Besten · 2019 to 2026
$4.5M
The stage-specific regulation of ameloblastin and enamelin by the distinct nuclear factorsR01DE027076 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yan Zhang · 2017 to 2026
$4.0M
The stage-specific regulation of ameloblastin and enamelin by the distinct nuclear factorsR56DE027076 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZHANG, YAN · 2022 to 2022
$323k
NIDCR NIH HHS R01 DE027076NIDCR NIH HHS R01 DE027971NIDCR NIH HHS R56 DE027076
6 · The paper itself

Abstract

Enamel development is a process in which extracellular matrix models from a soft proteinaceous matrix to the most mineralized tissue in vertebrates. Patients with mutant

Indexed as

ameloblast differentiationenamel biomineralizationextracellular matrix remodelingkallikrein-related peptidase 4K+-dependent Na+/Ca2+-exchangerproteinase activity

Identifiers

PMID36814474
PMCPMC9939835
OpenAlexW4319320925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.