Evidence map›Paper›PMID 36814249›Full record

SynthesisBMC gastroenterology2023

Frequency, outcomes, and need for intervention in stricturing gastrointestinal tuberculosis: a systematic review and meta-analysis.

Anuraag Jena, Ritin Mohindra, Kirtan Rana, Pardhu B Neelam, Dhuni Chand Thakur, Harjeet Singh, Pankaj Gupta, Vikas Suri, Vishal Sharma

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Outcomes of Abdominal Tuberculosis Referred for Surgical Management in a Tertiary Care Center in Nepal.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anuraag JenaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0001-9074-6698
Ritin MohindraDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0003-4224-898X
Kirtan RanaDepartment of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0001-9862-5700
Pardhu B NeelamDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0002-8531-461X
Dhuni Chand ThakurDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0003-3777-3368
Harjeet SinghDepartment of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0002-0748-9473
Pankaj GuptaDepartment of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0003-3914-3757
Vikas SuriDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.ORCID http://orcid.org/0000-0001-6379-2744
Vishal SharmaDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. sharma.vishal@pgimer.edu.in.ORCID http://orcid.org/0000-0003-2472-3409
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastrointestinal strictures impact clinical presentation in abdominal tuberculosis and are associated with significant morbidity.

aimTo conduct a systematic review of the prevalence of stricturing disease in abdominal and gastrointestinal tuberculosis and response to antitubercular therapy (ATT).

methodsWe searched Pubmed and Embase on 13th January 2022, for papers reporting on the frequency and outcomes of stricturing gastrointestinal tuberculosis. The data were extracted, and pooled prevalence of stricturing disease was estimated in abdominal tuberculosis and gastrointestinal (intestinal) tuberculosis. The pooled clinical response and stricture resolution (endoscopic or radiologic) rates were also estimated. Publication bias was assessed using the Funnel plot and Egger test. The risk of bias assessment was done using a modified Newcastle Ottawa Scale.

resultsThirty-three studies reporting about 1969 patients were included. The pooled prevalence of intestinal strictures in abdominal tuberculosis and gastrointestinal TB was 0.12 (95%CI 0.07-0.20, I

conclusionStricturing gastrointestinal tuberculosis occurs in around a quarter of patients with gastrointestinal tuberculosis, and around two-thirds of patients have a clinical response with antitubercular therapy. A subset of patients may need endoscopic or surgical intervention. The estimates for the pooled prevalence of stricturing disease and response to ATT had significant heterogeneity.

Indexed as

Intestinal ObstructionTuberculosis, GastrointestinalAbdomenAntitubercular AgentsConstriction, PathologicHumansAntitubercular AgentsAbdominal tuberculosisCrohn's diseaseGastrointestinal tuberculosisIntestinal tuberculosisPeritoneal tuberculosisTuberculous peritonitis

Identifiers

PMID36814249
PMCPMC9948355
OpenAlexW4321486805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.