ArticleAging clinical and experimental research2023
Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Understanding temporal changes in intrinsic capacity: analysis of domain-specific intrinsic capacity using SHARE data.GeroScience · 2026Article
- Intrinsic capacity across the adult lifespan in China: baseline analysis from the nationwide longitudinal PENG ZU cohort.GeroScience · 2026Article
- Article
- Living space, utilities, and communication access as determinants of intrinsic capacity: longitudinal findings from England and China.BMC geriatrics · 2026Article
- An assessment of intrinsic capacity among older Indian adults from the Longitudinal Ageing Study in India.Nature aging · 2025Article
- Intrinsic Capacity Predictors of Dementia and Mortality in the Sydney Memory and Ageing Study.International journal of geriatric psychiatry · 2025Article
- Factors Associated With Good Intrinsic Capacity in Community-Dwelling Older Adults.American journal of lifestyle medicine · 2025Article
- Healthy aging: how does a multidimensional construct of functional ability predict objective and subjective outcomes?BMC geriatrics · 2025Article
- A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors.Nature aging · 2025Article
- Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts.Nature aging · 2025Article
- The Longitudinal Aging Study Amsterdam: design and cohort update 2025.European journal of epidemiology · 2025Article
- A functional approach to model intrinsic capacity in ageing trajectories.Scientific reports · 2025Article
- Investigating Resilience Through Intrinsic Capacity Networks in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Impact of Exercise and Cognitive Stimulation Therapy on Intrinsic Capacity Composite Score in Pre-Frail Older Adults: A Pre-Post Intervention Study.The Journal of frailty & aging · 2024Article
- The Challenge of Measuring Intrinsic Capacity.The journal of nutrition, health & aging · 2023Article
- Association between Muscle Fatigability, Self-Perceived Fatigue and C-Reactive Protein at Admission in Hospitalized Geriatric Patients.International journal of environmental research and public health · 2023Article
- The icope Intrinsic Capacity Screening Tool: Measurement Structure and Predictive Validity of Dependence and Hospitalization.The journal of nutrition, health & aging · 2023Article
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6 authors.
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Abstract
backgroundIntrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person's IC is determined by its domain-specific indicators suggesting a formative measurement model.
aimsTo develop an IC score applying a formative approach and assess its validity.
methodsThe study sample (n = 1908) consisted of 57-88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year functional decline as an outcome. An IC score (range 0-100) was constructed for each participant. We examined the known-groups' validity of the IC score by comparing groups based on age and number of chronic diseases. The criterion validity of the IC score was assessed with 6-year functional decline and 10-year mortality as outcomes.
resultsThe constructed IC score included seven indicators covering all five domains of the construct. The mean IC score was 66.7 (SD 10.3). The scores were higher among younger participants and those who had lower number of chronic diseases. After adjustment for sociodemographic indicators, chronic diseases, and BMI, a one-point higher IC score was associated with a 7% decreased risk for 6-year functional decline and a 2% decreased risk for 10-year mortality.
conclusionsThe developed IC score demonstrated discriminative ability according to age and health status and is associated with subsequent functional decline and mortality.
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