ArticleNature2023
Chemically defined cytokine-free expansion of human haematopoietic stem cells.
Abstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
41.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
96 citing papers in PubMed, 143 citations in OpenAlex.
- Activated protein C promotes hematopoietic stem and progenitor cell quiescence and engraftment.EMBO molecular medicine · 2026Article
- ANGPTL8 induces the aging of hematopoietic stem/progenitor cells.Biogerontology · 2026Article
- CAR design equips diverse immune cells with unique antigen-specific activation identities.Molecular therapy. Oncology · 2026Article
- Serotype-specific effects of adenovirus 5 and 52 E4ORF1 proteins on endothelial cell-mediated regulation of hematopoietic stem cell expansion and lineage differentiation.In vitro cellular & developmental biology. Animal · 2026Article
- Ex vivo expansion of hematopoietic stem and progenitor cells from human mobilized peripheral blood for gene therapy applications.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Red blood cell differentiation using canine-induced pluripotent stem cells.Stem cells translational medicine · 2026Article
- Endosteal integrin-α8⁺ mesenchymal stem cells maintain haematopoietic stem cell function via extracellular matrix-mediated interactions.Nature communications · 2026Article
- Engineered Neutrophils in Translational Medicine: Gene Editing, Nanotechnology, and AI-Driven Clinical Breakthroughs.Advanced healthcare materials · 2026Review
- Ferrostatin-1 and hinokitiol supplementation enhance human hematopoietic stem cell expansion in a chemically defined medium.Molecular therapy. Advances · 2026Article
- Engineered human plasma-derived cryogels as a multifunctional scaffold to promote diabetic wound healing.Materials today. Bio · 2026Article
- Selection of human hematopoietic stem cells bearing the intended functional edit by transient AND-gate reporters.Nature biotechnology · 2026Article
- VLA-4 agonist promotes engraftment and immune reconstitution of allogeneic hematopoietic stem cells.Blood advances · 2026Article
- Recent advances in the construction of humanized animal models and applications in translational medicine.Animal models and experimental medicine · 2026Review
- Interleukin-12 Supports Self-renewal Division of Mouse Hematopoietic Stem Cells in Polyvinyl Alcohol-Based Culture.Stem cell reviews and reports · 2026Article
- Evaluation of the Effects of 50 Hz Magnetic Field Exposure on the Human Hematopoietic System in Humanized Mice.Bioelectromagnetics · 2026Article
- Efficient and robust generation of functional hematopoietic cells from human pluripotent stem cells in albumin-free conditions.Stem cells translational medicine · 2026Article
- Intravenous administration of ex vivo expanded human umbilical cord blood-derived CD34⁺ cells in a preterm hypoxic-ischemic encephalopathy mouse model.Scientific reports · 2026Article
- Hematopoietic stem and progenitor cell hierarchy is established by thrombopoietin-driven neonatal hematopoiesis.Stem cell reports · 2026Article
- Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells.Cell research · 2026Article
- Optimizing the Method for Differentiation of Functional Platelets from Human Induced Pluripotent Stem Cells.Stem cell reviews and reports · 2026Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 5 countries.
Masatoshi Sakurai *Division of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6687-4136
Kantaro Ishitsuka *Laboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Ryoji ItoHuman Disease Model Laboratory, Central Institute for Experimental Animals, Kawasaki, Japan.ORCID http://orcid.org/0000-0003-2903-2332
Adam C WilkinsonDivision of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-7406-0151
Takaharu KimuraLaboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Eiji MizutaniLaboratory of Stem Cell Therapy, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0000-0003-0301-6780
Hidekazu NishikiiDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0000-0002-6277-4082
Kazuhiro SudoCell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Japan.
Hans Jiro BeckerDivision of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3058-9859
Hiroshi TakemotoDepartment of Neuroscience, Drug Discovery and Disease Research Laboratory, Shionogi; Business-Academia Collaborative Laboratory (Shionogi), Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9893-0609
Tsubasa SanoPharma Solutions, Nutrition and Health, BASF Japan, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7979-4143
Keisuke KataokaDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Satoshi TakahashiDivision of Clinical Precision Research Platform, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0002-1076-2338
Yukio NakamuraCell Engineering Division, RIKEN BioResource Research Center, Tsukuba, Japan.ORCID http://orcid.org/0000-0001-6834-4123
David G KentDepartment of Biology, York Biomedical Research Institute, University of York, York, UK.ORCID http://orcid.org/0000-0001-7871-8811
Atsushi IwamaDivision of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-9410-8992
Shigeru ChibaDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Shinichiro OkamotoDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiromitsu NakauchiInstitute for Stem Cell Biology and Regenerative Medicine, Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. nakauchi@stanford.edu.ORCID http://orcid.org/0000-0002-9841-6973
Satoshi YamazakiDivision of Stem Cell Biology, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. y-sato4@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0003-4249-3854
University of Tsukuba · JPKeio University · JPRIKEN BioResource Research Center · JPThe University of Tokyo · JPCentral Institute for Experimental Animals · JPInstitute for Stem Cell Biology and Regenerative Medicine · INShionogi (Japan) · JPUniversity of Oxford · GBWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
Modulating HSC-niche interactions to understand aging and improve transplantationR01HL147124 · NHLBI · STANFORD UNIVERSITY · PI NAKAUCHI, HIROMITSU · 2018 to 2021
$1.6MOrigin of latent hematopoietic stem cells in the aged bone marrowR21AG061487 · NIA · STANFORD UNIVERSITY · PI NAKAUCHI, HIROMITSU · 2019 to 2020
$448kMedical Research Council MC_PC_19056Medical Research Council MR/V005502/1National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/V001922/1NHLBI NIH HHS R01 HL147124NIA NIH HHS R21 AG061487
Abstract
Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and immune systems after transplantation and can be used as a curative cell therapy for a variety of haematological diseases
Indexed as
Cell Culture TechniquesCell ProliferationCytokinesHematopoietic Stem CellsAlbuminsCaprolactamClone CellsFetal BloodHematopoietic Stem Cell TransplantationHumansIndolesPhosphatidylinositol 3-KinasesPolymersPyrimidinesReceptors, ThrombopoietinSingle-Cell Gene Expression AnalysisAlbuminsCaprolactamCytokinesIndolesPhosphatidylinositol 3-KinasesPolymersPyrimidinesReceptors, ThrombopoietinUM171 compound
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.