ArticleNature2023
Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
38.5field-weighted citation impact, top 1% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Revisiting down syndrome through the lens of interferonopathy and innate immune dysregulation.Frontiers in immunology · 2026Pooled it
- T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review.Frontiers in immunology · 2026Pooled it
- Genetics of catatonia: a systematic review of case reports and a gene pathway analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- A Novel Sugar-Free Probiotic Oral Rinse Influences Oral Candida albicans in Children with Down Syndrome Post Complete Oral Rehabilitation: A Pilot Randomized Clinical Trial with 6-Month Follow-Up.Probiotics and antimicrobial proteins · 2026Trial
- Trial
- The Rash That Will Not Go Away.Clinical pediatrics · 2026Article
- Clinical considerations for immune dysregulation and immunodeficiency in Down syndrome.Journal of human immunity · 2026Review
- Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.Current opinion in rheumatology · 2026Review
- Progressive deterioration of adaptive immune repertoires in Down syndrome linked to interferon hyperactivity and lymphoid tissue disorganization.bioRxiv : the preprint server for biology · 2026Article
- Immune Dysregulation in Down Syndrome: Implications for Infectious Susceptibility and Vaccine Response.Journal of clinical immunology · 2026Review
- C5 inhibition restores B cell homeostasis and humoral immunity in CHAPLE disease patients.Journal of human immunity · 2026Article
- How I Treat: Immune dysregulation in Down syndrome.Journal of human immunity · 2026Review
- Human CD21Journal of human immunity · 2026Review
- Endocrine and Digestive Disorders Arising in Childhood in Down Syndrome and Their Cross-Talk.Nutrients · 2026Review
- Atypical B cells and inflammatory profiles delineate immunity to influenza vaccination in First Nations and non-Indigenous people with chronic multimorbidity.Nature communications · 2026Article
- Transcriptomic and proteomic evidence for noncanonical hydrogen sulfide metabolism and immune dysregulation in Down Syndrome.Scientific reports · 2026Article
- Opportunities for antenatal medical treatment of genetic conditions: the earlier, the better.Pediatric research · 2026Article
- Toward a monogenic architecture of human infections: From 1996 to 2026.Journal of human immunity · 2026Review
- Evidence of anti-corticotroph autoantibodies in Down syndrome with isolated adrenocorticotropic hormone deficiency: findings from a single case.Endocrine · 2026Article
- Atypical memory B cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19.JCI insight · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 6 institutions in 2 countries.
Louise MalleCenter for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roosheel S PatelCenter for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marta Martin-Fernandez *Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4671-6349
O Jay Stewart *Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6071-760X
Quentin PhilippotLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Sofija ButaCenter for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ashley RichardsonCenter for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1700-9162
Vanessa BarcessatPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0256-2862
Justin TaftCenter for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Julie SamuelsMindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5184-0390
Clotilde MircherInstitut Jérôme Lejeune, Paris, France.
Anne-Sophie RebillatInstitut Jérôme Lejeune, Paris, France.
Louise MaillebouisInstitut Jérôme Lejeune, Paris, France.
Marie Vilaire-MeunierInstitut Jérôme Lejeune, Paris, France.
Kevin TuballesPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5899-7080
Brad R RosenbergDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5885-1276
Rebecca TrachtmanDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jean-Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8335-0262
Sacha GnjaticPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5643-9520
Douglas BushDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dusan BogunovicCenter for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Dusan.Bogunovic@mssm.edu.ORCID http://orcid.org/0000-0002-9277-3232
Child Health and Development Institute · USIcahn School of Medicine at Mount Sinai · USFondation Jérôme-Lejeune · FRInserm · FRHoward Hughes Medical Institute · USNational Institutes of Health · US
Funding
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MMOUNT SINAI MEDICAL SCIENTIST TRAINING PROGRAMT32GM007280 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI BARON, MARGARET H · 1985 to 2021
$22.8MHigh-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sacha Gnjatic, Seunghee Kim-Schulze · 2017 to 2026
$21.5MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MMount Sinai Medical Scientist Training ProgramT32GM146636 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Talia H Swartz · 2022 to 2026
$6.8MNext Generation Resolution of Antiviral Gene NetworksR01AI151029 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dusan Bogunovic, Brad Rosenberg · 2020 to 2026
$4.2MType I Interferon Dysregulation in Down SyndromeR01AI150300 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOGUNOVIC, DUSAN · 2019 to 2021
$3.8MCharacterizing and predicting colitis in immune checkpoint blockade-treated cancer patientsU01DK124165 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLOMBEL, JEAN-FREDERIC, FAITH, JEREMIAH JAMES · 2020 to 2024
$2.9MInterdisciplinary Training in Systems and Developmental Biology and Birth DefectsT32HD075735 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JABS, ETHYLIN WANG · 2013 to 2022
$1.8MNCI NIH HHS P30 CA196521NCI NIH HHS U24 CA224319NIAID NIH HHS R01 AI150300NIAID NIH HHS R01 AI151029NICHD NIH HHS T32 HD075735NIDDK NIH HHS U01 DK124165NIGMS NIH HHS T32 GM007280NIGMS NIH HHS T32 GM146636
Abstract
Down's syndrome (DS) presents with a constellation of cardiac, neurocognitive and growth impairments. Individuals with DS are also prone to severe infections and autoimmunity including thyroiditis, type 1 diabetes, coeliac disease and alopecia areata
Indexed as
AutoimmunityCD4-Positive T-LymphocytesCytokinesDown SyndromeAutoantibodiesB-LymphocytesDisease SusceptibilityHumansImmunoglobulin Heavy ChainsIntegrin alpha ChainsInterleukin-6Receptors, Antigen, B-CellReceptors, Complement 3dT-bet Transcription FactorAutoantibodiesCytokinesIGHV1-69 protein, humanIGHV4-34 protein, humanImmunoglobulin Heavy ChainsIntegrin alpha ChainsInterleukin-6ITGAX protein, humanReceptors, Antigen, B-CellReceptors, Complement 3dT-bet Transcription Factor
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.