ArticleNature2023
Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 289 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
289citing papers in PubMed, 4 pooled it
70.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
289 citing papers in PubMed, 4 syntheses or guidelines pooled it, 423 citations in OpenAlex.
- Modern Approaches to Diagnosis and Evaluation of Survival Prognosis in Patients with Pancreatic Cancer.International journal of molecular sciences · 2026Pooled it
- Bibliometric analysis of human microbiota-associated animal model (2005-2025).Frontiers in microbiology · 2026Pooled it
- Bibliometric analysis of the trends in research on the link between gut microbiota and pancreatic cancer.Frontiers in cellular and infection microbiology · 2026Pooled it
- Gut microbiota and gastrointestinal tumors: insights from a bibliometric analysis.Frontiers in microbiology · 2025Pooled it
- Trial
- Gut microbiota shaping fatty liver disease progression.Life science alliance · 2027Review
- Microbiota as a modulator of drug response: targeting microbial-drug crosstalk in cancer therapy.Gut microbes · 2026Review
- Multi-omics analysis of saccharomyces boulardii supplementation reveals coordinated microbiome, metabolic, and immune signaling changes accompanying tumor suppression.Gut microbes · 2026Article
- Isolation of Bacteria and Fungi from Human Pancreatic Tumors and Duodenum.Gut microbes · 2026Article
- Microbiota-derived self-adjuvanting exopolysaccharide-based codelivery system for potent cancer immunotherapy.Materials today. Bio · 2026Article
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Low-protein diet enhances antitumor immunity in pancreatic cancer through microbiota-derived UDP-galactose.Nature cancer · 2026Article
- Microbiome-based diagnostic biomarkers in pancreatic ductal adenocarcinoma: Current evidence and translational challenges (Review).Oncology letters · 2026Review
- Review
- Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds.Nature reviews. Gastroenterology & hepatology · 2026Review
- Novel insight into the effects of the metabolites from gut microbiota in both unmedicated depressive adolescents and mice: key roles of indole derivatives-aryl hydrocarbon receptor signaling in neurogenesis and microglial homeostasis.Molecular psychiatry · 2026Article
- FASTINA - protocol for a randomised feasibility trial of time-restricted eating to improve response to multiple myeloma therapy.Pilot and feasibility studies · 2026Article
- Microbiome-pancreatic cancer crosstalk: From tumor biology to therapeutic intervention.iMetaOmics · 2026Review
- Tryptophan metabolism in tumor microenvironment and therapeutic implications.Journal of advanced research · 2026Review
229 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
31 authors at 7 institutions in 4 countries.
Joseph TintelnotII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. j.tintelnot@uke.de.ORCID http://orcid.org/0000-0003-4619-9433
Yang XuDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Till R LeskerResearch Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Martin SchönleinII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-1010-0975
Leonie KonczallaMildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7674-1276
Anastasios D GiannouDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Penelope PelczarI. Department of Medicine, University Medical Center Hamburg- Eppendorf, Hamburg, Germany.
Dominik KyliesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Victor G PuellesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7735-5462
Agata A BieleckaResearch Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Manuela PeschkaInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Filippo CortesiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kristoffer RieckenResearch Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-9050-6766
Maximilian JungResearch Department Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Lena AmendResearch Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-5066-7140
Tobias S BröringDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marija Trajkovic-ArsicBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jens T SivekeBridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-8772-4778
Thomas RennéInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Danmei ZhangDepartment of Internal Medicine III, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany.ORCID http://orcid.org/0000-0001-6048-4711
Stefan BoeckDepartment of Internal Medicine III, Ludwig-Maximilians-University (LMU) Hospital, Munich, Germany.ORCID http://orcid.org/0000-0002-1922-2127
Till StrowigResearch Group Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-0185-1459
Faik G UzunogluDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Cenap GüngörDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5173-9492
Alexander SteinII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jakob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Carsten BokemeyerII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marianne SinnII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Alec C KimmelmanDepartment of Radiation Oncology, Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY, USA.
Samuel Huber *I. Department of Medicine, University Medical Center Hamburg- Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-9325-8227
Nicola Gagliani *Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. n.gagliani@uke.de.ORCID http://orcid.org/0000-0001-8514-1395
Universität Hamburg · DEHelmholtz Centre for Infection Research · DEGerman Cancer Research Center · DELudwig-Maximilians-Universität München · DEMedizinische Hochschule Hannover · DENew York University · USRoyal College of Surgeons in Ireland · IE
Funding
Identifying Metabolic Dependencies of Pancreatic CancersR35CA232124 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIMMELMAN, ALEC · 2018 to 2024
$6.5MAbstract
Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment
Indexed as
Carcinoma, Pancreatic DuctalMicrobiotaPancreatic NeoplasmsAnimalsAutophagyDisease Models, AnimalFecal Microbiota TransplantationGerm-Free LifeGlutathione PeroxidaseHumansIndoleacetic AcidsMetabolomicsMetagenomeMiceNeutrophilsPeroxidaseGlutathione Peroxidaseindoleacetic acidIndoleacetic AcidsPeroxidaseReactive Oxygen SpeciesTryptophan
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.