ArticleThe ISME journal2023
Cell aggregation is associated with enzyme secretion strategies in marine polysaccharide-degrading bacteria.
Article in The ISME journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 42 citations in OpenAlex.
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- Sticky enzymes: increased metabolic efficiency via substrate-dependent enzyme clustering.PRX life · 2025Article
- HABS-BLOCKS© InhibitedMicroorganisms · 2025Article
- Insights into putative alginate lyases from epipelagic and mesopelagic communities of the global ocean.Scientific reports · 2025Article
- Differential aggregation patterns of Endozoicomonas within tissues of the coral Acropora loripes.The ISME journal · 2025Article
- Structural characterization and preliminary functional evaluation of a novel Polysaccharide NS0-1 fromCurrent research in food science · 2025Article
- A framework for understanding collective microbiome metabolism.Nature microbiology · 2024Review
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- Bacteria face trade-offs in the decomposition of complex biopolymers.PLoS computational biology · 2024Article
- Microfluidic approaches in microbial ecology.Lab on a chip · 2024Review
- Physicochemical profiles of mixed ruminal microbes in response to surface tension and specific surface area.Frontiers in veterinary science · 2024Article
- Minorities drive growth resumption in cross-feeding microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Interspecies interactions determine growth dynamics of biopolymer-degrading populations in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Phenotypic and metabolic adaptations ofFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polysaccharide breakdown by bacteria requires the activity of enzymes that degrade polymers either intra- or extra-cellularly. The latter mechanism generates a localized pool of breakdown products that are accessible to the enzyme producers themselves as well as to other organisms. Marine bacterial taxa often show marked differences in the production and secretion of degradative enzymes that break down polysaccharides. These differences can have profound effects on the pool of diffusible breakdown products and hence on the ecological dynamics. However, the consequences of differences in enzymatic secretions on cellular growth dynamics and interactions are unclear. Here we study growth dynamics of single cells within populations of marine Vibrionaceae strains that grow on the abundant marine polymer alginate, using microfluidics coupled to quantitative single-cell analysis and mathematical modelling. We find that strains that have low extracellular secretions of alginate lyases aggregate more strongly than strains that secrete high levels of enzymes. One plausible reason for this observation is that low secretors require a higher cellular density to achieve maximal growth rates in comparison with high secretors. Our findings indicate that increased aggregation increases intercellular synergy amongst cells of low-secreting strains. By mathematically modelling the impact of the level of degradative enzyme secretion on the rate of diffusive oligomer loss, we find that enzymatic secretion capability modulates the propensity of cells within clonal populations to cooperate or compete with each other. Our experiments and models demonstrate that enzymatic secretion capabilities can be linked with the propensity of cell aggregation in marine bacteria that extracellularly catabolize polysaccharides.
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