ArticleJournal of perinatology : official journal of the California Perinatal Association2023
Short-course empiric antibiotic therapy for possible early-onset sepsis in the NICU.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Evaluating the duration of post-discontinuation therapeutic ampicillin exposures in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Revisiting time to blood culture positivity: can we decrease antibiotic exposure in the NICU?Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- The Angel in the Marble: Antibiotic Duration in the Neonatal Intensive Care Unit.Antibiotics (Basel, Switzerland) · 2026Review
- Congenital HSV-2 infection with atypical skin lesions, chorioretinitis, and neurodevelopmental sequelae: a case report.BMC pregnancy and childbirth · 2026Article
- Time to positive blood cultures in neonatal sepsis evaluations.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Antibiotic exposure for culture-negative early-onset sepsis in late-preterm and term newborns: an international study.Pediatric research · 2025Article
- Antibiotic use among extremely low birth-weight infants from 2009 to 2021: a retrospective observational study.Archives of disease in childhood. Fetal and neonatal edition · 2025Observational
- Gentamicin Pharmacokinetics in Neonates Undergoing Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy.Paediatric drugs · 2025Article
- Investigating antibiotics in the NICU and patient safety.Frontiers in cellular and infection microbiology · 2025Review
- Antibiotic Use in Late Preterm and Full-Term Newborns.JAMA network open · 2024Observational
- New strategies to Reduce Unnecessary Antibiotic Use in the NICU: A Quality Improvement Initiative.Pediatric quality & safetyArticle
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Authors and funding
11 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOn 2/2019, the Neonatal Antimicrobial Stewardship Program at Nationwide Children's Hospital recommended reducing empirical antibiotic therapy for early-onset sepsis (EOS) from 48 to 24 hours with a TIME-OUT. We describe our experience with this guideline and assess its safety.
methodsRetrospective review of newborns evaluated for possible EOS at 6 NICUs from 12/2018-7/2019. Safety endpoints were re-initiation of antibiotics within 7 days after discontinuation of the initial course, positive bacterial blood or cerebrospinal fluid culture in the 7 days after antibiotic discontinuation, and overall and sepsis-related mortality.
resultAmong 414 newborns evaluated for EOS, 196 (47%) received a 24 hour rule-out sepsis antibiotic course while 218 (53%) were managed with a 48 hour course. The 24-hour rule-out group were less likely to have antibiotics re-initiated and did not differ in the other predefined safety endpoints.
conclusionAntibiotic therapy for suspected EOS may be discontinued safely within 24 hours.
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Registered trials
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