Evidence map›Paper›PMID 36813289›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2023

Diagnostic workup of childhood interstitial lung disease.

Nadia Nathan, Matthias Griese, Katarzyna Michel, Julia Carlens, Carlee Gilbert, Nagehan Emiralioglu, Alba Torrent-Vernetta, Honorata Marczak, Brigitte Willemse, Céline Delestrain and 2 more

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Old and emerging therapies for childhood interstitial lung disease (chILD): a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Interstitial lung disease and the STING pathway.The Journal of clinical investigation · 2026
    Review
  8. Article
  9. Occult Childhood Interstitial Lung Disease.Balkan medical journal · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Pulmonary alveolar proteinosis andFrontiers in pediatrics · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nadia NathanAP-HP, Sorbonne Université, Pediatric Pulmonology Department and Reference Center for Rare Lung Disease RespiRare, Armand Trousseau Hospital, Paris, France nadia.nathan@aphp.fr.ORCID https://orcid.org/0000-0001-5149-7975
Matthias GrieseDepartment of Paediatric Pneumology, Dr von Hauner Children's Hospital, German Centre for Lung Research, University of Munich, Munich, Germany.
Katarzyna MichelDepartment of Paediatric Pneumology, Dr von Hauner Children's Hospital, German Centre for Lung Research, University of Munich, Munich, Germany.
Julia CarlensClinic for Pediatric Pneumology, Hannover Medical School, Hannover, Germany.
Carlee GilbertInstitute of Population Health, University of Liverpool, Liverpool, UK.ORCID https://orcid.org/0000-0002-5340-5728
Nagehan EmiraliogluDepartment of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey.ORCID https://orcid.org/0000-0002-1405-8401
Alba Torrent-VernettaPediatric Allergy and Pulmonology Section, Department of Pediatrics, Vall d'Hebron Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0002-3575-2427
Honorata MarczakCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Brigitte WillemseDepartment of Pediatric Pneumology and Allergy, Medical University of Warsaw, Warsaw, Poland.
Céline DelestrainDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ralph EpaudCentre Hospitalier Intercommunal de Créteil, Service de Pédiatrie Générale, Créteil, France.ORCID https://orcid.org/0000-0003-3830-1039
ERS CRC chILD-EU group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Childhood interstitial lung diseases (chILDs) are rare and heterogeneous diseases with significant morbidity and mortality. An accurate and quick aetiological diagnosis may contribute to better management and personalised treatment. On behalf of the European Respiratory Society Clinical Research Collaboration for chILD (ERS CRC chILD-EU), this review summarises the roles of the general paediatrician, paediatric pulmonologists and expert centres in the complex diagnostic workup. Each patient's aetiological chILD diagnosis must be reached without prolonged delays in a stepwise approach from medical history, signs, symptoms, clinical tests and imaging, to advanced genetic analysis and specialised procedures including bronchoalveolar lavage and biopsy, if necessary. Finally, as medical progress is fast, the need to revisit a diagnosis of "undefined chILD" is stressed.

Indexed as

Lung Diseases, InterstitialBiopsyBronchoalveolar LavageChildDiagnostic ImagingHumansLungMorbidity

Identifiers

PMID36813289
PMCPMC9945877

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.