SynthesisNeuroscience and biobehavioral reviews2023
Neural correlates of impulsivity in bipolar disorder: A systematic review and clinical implications.
Synthesis in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial.Health technology assessment (Winchester, England) · 2025Trial
- A randomised double-blind, placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression (the PAX-BD study).Journal of psychopharmacology (Oxford, England) · 2025Trial
- Brain structural-functional connectivity coupling and glucose metabolism in adolescents with bipolar disorder and major depressive disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Suicidal ideation and cognitive function: a comparative study in adolescents with unipolar versus bipolar depression.European archives of psychiatry and clinical neuroscience · 2026Article
- Neural Markers of Reward Valuation and Impulsive Decision-Making in Mania Risk.JAMA psychiatry · 2026Article
- Elevated pre-supplementary motor area activity during reward expectancy: An impulsivity-related neural marker of vulnerability to bipolar and externalizing disorders.Molecular psychiatry · 2026Article
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Reward circuit local field potential modulations precede risk taking.Brain : a journal of neurology · 2025Article
- Neural representation of proactive and reactive inhibitory control adaptations across sensory modalities.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- The Mediation Role of Emotional Symptoms Between Impulsivity Traits and Problematic Gaming Behavior in Adolescents.Journal of adolescence · 2025Article
- Neuromodulation of the right inferior frontal gyrus in bipolar disorder to target response inhibition: a proof-of-concept study.CNS spectrums · 2025Article
- Transdiagnostic neuromodulation of impulsivity: current status and future trajectories.Translational psychiatry · 2025Review
- Impaired emotional response inhibition among adolescents with bipolar depression: evidence from event-related potentials and behavioral performance.BMC psychiatry · 2025Article
- Executive function performance in high and low medication adherent patients with euthymic bipolar i disorder: a comparative study.BMC psychiatry · 2025Article
- Review
- Exploring the Morphological Study of the Brain in Patients with Bipolar Disorder Based on Structural Magnetic Resonance Imaging.Neuropsychiatric disease and treatment · 2025Article
- Article
- Shaping decision-making with screen time: video-based dialectical behavior therapy skills training for college students.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Impulsivity is a common feature of bipolar disorder (BD) with ramifications for functional impairment and premature mortality. This PRISMA-guided systematic review aims to integrate findings on the neurocircuitry associated with impulsivity in BD. We searched for functional neuroimaging studies that examined rapid-response impulsivity and choice impulsivity using the Go/No-Go Task, Stop-Signal Task, and Delay Discounting Task. Findings from 33 studies were synthesized with an emphasis on the effect of mood state of the sample and affective salience of the task. Results suggest trait-like brain activation abnormalities in regions implicated in impulsivity that persist across mood states. During rapid-response inhibition, BD exhibit under-activation of key frontal, insular, parietal, cingulate, and thalamic regions, but over-activation of these regions when the task involves emotional stimuli. Delay discounting tasks with functional neuroimaging in BD are lacking, but hyperactivity of orbitofrontal and striatal regions associated with reward hypersensitivity may be related to difficulty delaying gratification. We propose a working model of neurocircuitry dysfunction underlying behavioral impulsivity in BD. Clinical implications and future directions are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.