Evidence map›Paper›PMID 36813138›Full record

ArticleToxicology and applied pharmacology2023

Examination of the exposome in an animal model: The impact of high fat diet and rat strain on local and systemic immune markers following occupational welding fume exposure.

K A Roach, V Kodali, M Shoeb, T Meighan, M Kashon, S Stone, W McKinney, A Erdely, P C Zeidler-Erdely, J R Roberts and 1 more

Open access · greenAbstract read
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In one paragraph

Article in Toxicology and applied pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

K A RoachAllergy and Clinical Immunology Branch (ACIB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA. Electronic address: WVQ1@cdc.gov.
V KodaliPathology and Physiology Research Branch (PPRB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
M ShoebPathology and Physiology Research Branch (PPRB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
T MeighanPathology and Physiology Research Branch (PPRB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
M KashonBioanalytics Branch (BB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
S StonePhysical Effects Research Branch (PERB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
W McKinneyPhysical Effects Research Branch (PERB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
A ErdelyPathology and Physiology Research Branch (PPRB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
P C Zeidler-ErdelyPathology and Physiology Research Branch (PPRB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
J R RobertsAllergy and Clinical Immunology Branch (ACIB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
J M AntoniniPathology and Physiology Research Branch (PPRB), National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV, USA.
National Institute for Occupational Safety and Health · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

The goal of this study was to investigate the impact of multiple exposomal factors (genetics, lifestyle factors, environmental/occupational exposures) on pulmonary inflammation and corresponding alterations in local/systemic immune parameters. Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. Welding fume (WF) exposure (inhalation) occurred between 7 and 12wk. Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. Indices of lung injury/inflammation were elevated in all WF-exposed animals at 12wk; however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. Overall, SD rats exhibited the greatest capacity for recovery by 24wk. In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. These results illustrate the combined impact of genetic, lifestyle, and environmental factors in modulating immunological responsivity and emphasize the importance of the exposome in shaping biological responses.

Indexed as

Air Pollutants, OccupationalExposomeLung InjuryOccupational ExposurePneumoniaWeldingAnimalsBiomarkersDiet, High-FatInflammationInhalation ExposureMaleRatsRats, Inbred BNRats, Sprague-DawleyAir Pollutants, OccupationalBiomarkersExposomeHigh fat dietImmunotoxicityIn vivo modelOccupational healthWelding fume

Identifiers

PMID36813138
PMCPMC10251237
OpenAlexW4321460154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.