Evidence map›Paper›PMID 36813025›Full record

ArticleThe American journal of clinical nutrition2023

Age-dependent associations of human milk oligosaccharides with body size and composition up to 4 years of age.

Toby Mansell, Annalee Furst, Martin O'Hely, Melinda Chang, Anne-Louise Ponsonby, Peter Vuillermin, Mimi Lk Tang, David Burgner, Richard Saffery, Lars Bode and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Toby MansellMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
Annalee FurstDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, California, United States.
Martin O'HelyMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; School of Medicine, Deakin University, Geelong, Australia.
Melinda ChangDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, California, United States.
Anne-Louise PonsonbyMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Peter VuillerminMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; School of Medicine, Deakin University, Geelong, Australia; Child Health Research Unit, Barwon Health, Geelong, Australia.
Mimi Lk TangMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
David BurgnerMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Paediatrics, Monash University, Clayton, Australia.
Richard SafferyMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
Lars BodeDepartment of Pediatrics and Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, California, United States. Electronic address: lbode@ucsd.edu.
Barwon Infant Study Investigator Group
Royal Children's Hospital · AUUniversity of California San Diego · USBarwon Health · AU

Funding

Exploring Associations between Human Milk Oligosaccharides and Atherosclerosis Risk Factors in Infancy and Early ChildhoodR21HD105186 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BODE, LARS · 2021 to 2022
$398k
NICHD NIH HHS R21 HD105186
6 · The paper itself

Abstract

backgroundHuman milk oligosaccharides (HMOs) are major components of human milk that may mediate its beneficial effects on infant growth.

objectivesTo investigate relationships between HMO concentrations in milk at 6 wk postpartum and anthropometry to 4 y of age in human milk-fed infants.

methodsMilk samples were collected from 292 mothers at 6 wk (median 6.0 wk; range 3.3, 11.1] postpartum in a longitudinal, population-derived cohort. Of the infants, 171 were exclusively human milk-fed to 3 mo of age and 127 to 6 mo. Concentrations of 19 HMOs were quantified using high-performance liquid chromatography. Maternal secretor status (n = 221 secretors) was determined from 2'-fucosyllactose (2'FL) concentration. We calculated z-scores for child weight, length, head circumference, summed triceps and subscapular skinfold thicknesses, and weight-for-length at 6 wk, 6 mo, 12 mo, and 4 y. We investigated associations of secretor status and each HMO measure with change from birth for each z-score using linear mixed-effects models.

resultsMaternal secretor status was not associated with anthropometric z-scores up to 4 y of age. Several HMOs were associated with z-scores at 6 wk and 6 mo, predominantly within secretor status subgroups. Higher levels of 2'FL were associated with greater weight [β = 0.91 increase in z-score per SD increase log-2'FL, 95% CI (0.17, 1.65)] and length [β = 1.22, (0.25, 2.20)] in children born to secretor mothers, but not body composition measures. Higher lacto-N-tetraose was associated with greater weight [β = 0.22, (0.02, 0.41)] and length (β = 0.30, (0.07, 0.53)] among children born to nonsecretor mothers. Several HMOs were associated with anthropometric measures at 12 mo and 4 y of age.

conclusionsMilk HMO composition at 6 wk postpartum is associated with several anthropometry measures up to 6 mo of age in a potential secretor status-specific manner, with largely different HMOs associating with anthropometry from 12 mo to 4 y of age.

Indexed as

Milk, HumanOligosaccharidesBody SizeChildFemaleHumansInfantMothersPostpartum PeriodOligosaccharides2’FLadiposityanthropometrygrowthhuman milk oligosaccharidessecretor

Identifiers

PMID36813025
PMCPMC10447468
OpenAlexW4321457762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.