ArticleCell2023
Bat pluripotent stem cells reveal unusual entanglement between host and viruses.
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Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
33.9field-weighted citation impact, top 1% of its field
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Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
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- From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines.Cells · 2025Article
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- Different Species of Bats: Genomics, Transcriptome, and Immune Repertoire.Current issues in molecular biology · 2025Review
- RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats.BMC genomics · 2025Article
- Understanding vertebrate immunity through comparative immunology.Nature reviews. Immunology · 2025Review
- Signature of viral fossils: a comparative genomics approach to understand the diversity of endogenous retroviruses in bats.Virus research · 2024Article
- Bats as instructive animal models for studying longevity and aging.Annals of the New York Academy of Sciences · 2024Review
Corrections and comments
- Commented on byBat crazy iPSCs.2023
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Authors and funding
25 authors at 11 institutions in 6 countries.
Marion DéjosezHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Paratus Sciences, 430 East 29th Street, Suite 600, New York, NY 10016, USA.
Arturo MarinDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Graham M HughesSchool of Biology and Environmental Science, University College Dublin, Ireland.
Ariadna E MoralesSenckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany; Faculty of Biosciences, Goethe University, Max-von-Laue-Str, 60438 Frankfurt, Germany.
Carlos Godoy-ParejoHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA.
Jonathan L GrayHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA.
Yiren QinHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA.
Arun A SinghHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA.
Hui XuHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA.
Javier JusteEstación biológica de doñana (CSIC), Avda. Américo Vespucio 26, Seville 41092, Spain; CIBER Epidemiology and Public Health, CIBERESP, Madrid, Spain.
Carlos IbáñezEstación biológica de doñana (CSIC), Avda. Américo Vespucio 26, Seville 41092, Spain.
Kris M WhiteDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Romel RosalesDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Nancy J FrancoeurPacific Biosciences, Menlo Park, CA, USA.
Robert P SebraDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Icahn Institute for Genomics, New York, NY, USA.
Dominic AlcockSchool of Biology and Environmental Science, University College Dublin, Ireland.
Thomas L VolkertParatus Sciences, 430 East 29th Street, Suite 600, New York, NY 10016, USA.
Sébastien J PuechmailleISEM, University of Montpellier, Montpellier, France.
Andrzej PastusiakMicrosoft Premonition, Microsoft Building 99, 14820 NE 36th Street, Redmond, WA 98052, USA.
Simon D W FrostMicrosoft Premonition, Microsoft Building 99, 14820 NE 36th Street, Redmond, WA 98052, USA; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Michael HillerLOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany; Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany; Faculty of Biosciences, Goethe University, Max-von-Laue-Str, 60438 Frankfurt, Germany.
Richard A YoungWhitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Emma C TeelingSchool of Biology and Environmental Science, University College Dublin, Ireland. Electronic address: emma.teeling@ucd.ie.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular and Cell-Based Medicine and the Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.
Thomas P ZwakaHuffington Center for Cell-Based Research in Parkinson's disease, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Department of Cell, Developmental, and Regenerative Biology, and Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10502, USA; Paratus Sciences, 430 East 29th Street, Suite 600, New York, NY 10016, USA. Electronic address: thomas.zwaka@mssm.edu.
Icahn School of Medicine at Mount Sinai · USUniversity College Dublin · IECentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESEstación Biológica de Doñana · ESInstitut des Sciences de l'Evolution de Montpellier · FRLOEWE Centre for Translational Biodiversity Genomics · DEMassachusetts Institute of Technology · USMicrosoft (United States) · USPacific Biosciences (United States) · USSenckenberg Research Institute and Natural History Museum Frankfurt/M · DEUniversity of London · GB
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MSARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2MTranscriptional regulation in mammalian cellsR35GM144283 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI RICHARD YOUNG · 2022 to 2026
$4.0MPhase II - Development of a Prophylactic Onchocerciasis Vaccine75N93019C00028 · NIAID · PAI LIFE SCIENCES, INC. · PI CARTER, DARRICK · 2019 to 2019
$3.0MAn inquiry into the function of Ronin in embryogenesis and pluripotent stem cellsR01GM129329 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZWAKA, THOMAS P. · 2018 to 2021
$1.9MProtection of early embryogenesis and pluripotent stem cells against genetic parasites through a primitive immune systemR01HD100518 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ZWAKA, THOMAS P. · 2020 to 2024
$1.7MNCATS NIH HHS UL1 TR004419NIAID NIH HHS 75N93019C00028NIAID NIH HHS U19 AI135972NICHD NIH HHS R01 HD100518NIGMS NIH HHS R01 GM129329NIGMS NIH HHS R35 GM144283
Abstract
Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However, there are currently no reliable cellular models for studying bat biology or their response to viral infections. Here, we created induced pluripotent stem cells (iPSCs) from two species of bats: the wild greater horseshoe bat (Rhinolophus ferrumequinum) and the greater mouse-eared bat (Myotis myotis). The iPSCs from both bat species showed similar characteristics and had a gene expression profile resembling that of cells attacked by viruses. They also had a high number of endogenous viral sequences, particularly retroviruses. These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences and may have a more intertwined relationship with viruses than previously thought. Further study of bat iPSCs and their differentiated progeny will provide insights into bat biology, virus host relationships, and the molecular basis of bats' special traits.
Indexed as
ChiropteraPluripotent Stem CellsVirus DiseasesVirusesAnimalsPhylogenyTranscriptomebatscancercoronavirusesdifferentiationendogenized virusesepigeneticsevolutionhost-pathogen-interactionsinduced pluripotent stem cellsinflammationvirus response
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