Evidence map›Paper›PMID 36812809›Full record

ArticlePsychiatry research. Neuroimaging2023

Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents.

Matthew D Albaugh, James J Hudziak, Philip A Spechler, Bader Chaarani, Claude Lepage, Seun Jeon, Pierre Rioux, Alan C Evans, Tobias Banaschewski, Arun L W Bokde and 19 more

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In one paragraph

Article in Psychiatry research. Neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 12 institutions in 7 countries.

Matthew D AlbaughDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States of America. Electronic address: malbaugh@uvm.edu.
James J HudziakDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States of America.
Philip A SpechlerDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States of America.
Bader ChaaraniDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States of America.
Claude LepageMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Seun JeonMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Pierre RiouxMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Alan C EvansMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland.
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, United Kingdom.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany [or depending on journal requirements can be: Physikalisch-Technische Bundesanstalt (PTB), Abbestr. 2 - 12, Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, CNRS, Ecole Normale Supérieure Paris-Saclay, Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM U 1299 "Trajectoires développementales & psychiatrieȝ, University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-sur-Yvette, Paris; France; AP-HP. Sorbonne University, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris; France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str. 5, 37075, Göttingen, Germany.
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin, Germany; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.
Alexandra S PotterDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States of America.
Hugh GaravanDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, United States of America.
IMAGEN Consortium
University of Vermont · USMontreal Neurological Institute and Hospital · CAÉcole Normale Supérieure Paris-Saclay · FRHeidelberg University · DETrinity College Dublin · IECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHumboldt-Universität zu Berlin · DEKing's College London · GBPhysikalisch-Technische Bundesanstalt · DEUniversity of Göttingen · DEUniversity of Mannheim · DEUniversity of Nottingham · GB

Funding

Vermont Center on Behavior and HealthP20GM103644 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HIGGINS, STEPHEN T · 2013 to 2022
$21.3M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
Development and clinical validation of multimodal risk algorithms for predicting future internalizing psychopathologyK08MH121654 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ALBAUGH, MATTHEW D · 2020 to 2023
$737k
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
Medical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1Medical Research Council MR/W002418/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIGMS NIH HHS P20 GM103644NIMH NIH HHS K08 MH121654NIMH NIH HHS R01 MH085772
6 · The paper itself

Abstract

Few studies have examined the association between conduct problems and cerebral cortical development. Herein, we characterize the association between age-related brain change and conduct problems in a large longitudinal, community-based sample of adolescents. 1,039 participants from the IMAGEN study possessed psychopathology and surface-based morphometric data at study baseline (M = 14.42 years, SD = 0.40; 559 females) and 5-year follow-up. Self-reports of conduct problems were obtained using the Strengths and Difficulties Questionnaire (SDQ). Vertex-level linear mixed effects models were implemented using the Matlab toolbox, SurfStat. To investigate the extent to which cortical thickness maturation was qualified by dimensional measures of conduct problems, we tested for an interaction between age and SDQ Conduct Problems (CP) score. There was no main effect of CP score on cortical thickness; however, a significant "Age by CP" interaction was revealed in bilateral insulae, left inferior frontal gyrus, left rostral anterior cingulate, left posterior cingulate, and bilateral inferior parietal cortices. Across regions, follow-up analysis revealed higher levels of CP were associated with accelerated age-related thinning. Findings were not meaningfully altered when controlling for alcohol use, co-occurring psychopathology, and socioeconomic status. Results may help to further elucidate neurodevelopmental patterns linking adolescent conduct problems with adverse adult outcomes.

Indexed as

Cerebral CortexMagnetic Resonance ImagingAdolescentAdultEmotionsFemaleHumansParietal LobePrefrontal CortexBrain developmentConduct problemsCortical thicknessExternalizing

Identifiers

PMID36812809
PMCPMC12573193
OpenAlexW4320921313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.