Evidence map›Paper›PMID 36812482›Full record

ArticleAging2023

Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice.

Jun Yan, Te Liu, Yang Li, Jun Zhang, Bo Shi, Fuqiang Zhang, Xuejia Hou, Xiaowen Zhang, Wanxing Cui, Jing Li and 4 more

Open access · hybridFull text read
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. VCAM-1Neurochemical research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Jun YanDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Te LiuDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Yang LiDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Jun ZhangDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Bo ShiDepartment of Anesthesiology, The First Hospital of Jilin University, Changchun 130000, Jilin, China.
Fuqiang ZhangDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Xuejia HouDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Xiaowen ZhangDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Wanxing CuiGeorgetown University Hospital, Washington, DC 20007, USA.
Jing LiDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Hua YaoDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Xiuying LiDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Yufei GaoDepartment of Neurosurgery, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin, China.
Jinlan JiangDepartment of Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin, China.
Union Hospital · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells are a potential therapeutic candidate for cerebral infarction due to their anti-inflammatory proprieties. However, ensuring the engraftment of sufficient cells into the affected brain area remains a challenge. Herein, magnetic targeting techniques were used for the transplantation of a large number of cells noninvasively. Mice subjected to pMCAO surgery were administered MSCs labeled or not with iron oxide@polydopamine nanoparticles by tail vein injection. Iron oxide@polydopamine particles were characterized by transmission electron microscopy, and labeled MSCs were characterized by flow cytometry and their differentiation potential was assessed

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsCerebral InfarctionFerric CompoundsHumansIndolesMicePolymersUmbilical CordFerric Compoundsferric oxideIndolespolydopaminePolymerscerebral infarctionhuman umbilical cord mesenchymal stem cellinflammationiron oxide nanoparticle

Identifiers

PMID36812482
PMCPMC10008509
OpenAlexW4321501688

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read26
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.