Evidence map›Paper›PMID 36812441›Full record

ArticleThe New England journal of medicine2023

Safety and Efficacy of Denosumab for Fibrous Dysplasia of Bone.

Luis F de Castro, Zachary Michel, Kristen Pan, Jocelyn Taylor, Vivian Szymczuk, Sriram Paravastu, Babak Saboury, Georgios Z Papadakis, Xiaobai Li, Kelly Milligan and 4 more

Open access · greenAbstract readLetter
In one paragraph

Article in The New England journal of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Comparison of traditional and new treatments for fibrous dysplasia: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
  3. Pooled it
  4. Trial
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  6. No overshoot of bone turnover after withdrawal of denosumab treatment of adults with Langerhans cell histiocytosis: a prospective clinical trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Trial
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  14. Article
  15. [Research progress on external cervical resorption].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  16. Article
  17. Burosumab treatment for FGF23-related hypophosphatemia in a two-year-old girl with McCune-Albright syndrome.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Luis F de CastroNational Institutes of Health, Bethesda, MD.
Zachary MichelNational Institutes of Health, Bethesda, MD.
Kristen PanNational Institutes of Health, Bethesda, MD.
Jocelyn TaylorNational Institutes of Health, Bethesda, MD.
Vivian SzymczukNational Institutes of Health, Bethesda, MD.
Sriram ParavastuNational Institutes of Health, Bethesda, MD.
Babak SabouryNational Institutes of Health, Bethesda, MD.ORCID 0000-0002-8632-6292
Georgios Z PapadakisFoundation for Research and Technology, Heraklion, Greece.
Xiaobai LiNational Institutes of Health, Bethesda, MD.
Kelly MilliganNational Institutes of Health, Bethesda, MD.
Brendan BoyceUniversity of Rochester Medical Center, Rochester, NY.
Scott M PaulNational Institutes of Health, Bethesda, MD alison.boyce@nih.gov.
Michael T CollinsNational Institutes of Health, Bethesda, MD alison.boyce@nih.gov.
Alison M BoyceNational Institutes of Health, Bethesda, MD alison.boyce@nih.gov.ORCID 0000-0003-2987-3887
National Institutes of Health · USFoundation for Research and Technology Hellas · GRUniversity of Rochester Medical Center · US

Funding

Metabolic Bone Disorders UnitZIADE000758 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI BOYCE, ALISON · 2021 to 2025
$8.9M
Intramural NIH HHS ZIA DE000758NIDCR NIH HHS 1ZIADE000758
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bone Density Conservation AgentsDenosumabFibrous Dysplasia of BoneHumansTreatment OutcomeBone Density Conservation AgentsDenosumab

Identifiers

PMID36812441
PMCPMC10015375
OpenAlexW4321482772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.