Evidence map›Paper›PMID 36812385›Full record

ArticleEnvironmental science & technology2023

Persistence of Human Norovirus (GII) in Surface Water: Decay Rate Constants and Inactivation Mechanisms.

Lauren C Kennedy, Veronica P Costantini, Kimberly A Huynh, Stephanie K Loeb, Wiley C Jennings, Sarah Lowry, Mia C Mattioli, Jan Vinjé, Alexandria B Boehm

Open access · hybridAbstract read
In one paragraph

Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lauren C KennedyDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-4451-2361
Veronica P CostantiniDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.
Kimberly A HuynhDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.
Stephanie K LoebDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-8666-518X
Wiley C JenningsDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California 94305, United States.
Sarah LowryDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California 94305, United States.
Mia C MattioliDivision of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.
Jan VinjéDivision of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States.
Alexandria B BoehmDepartment of Civil and Environmental Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-8162-5090
Centers for Disease Control and Prevention · USStanford University · USMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human norovirus (HuNoV) is an important cause of acute gastroenteritis and can be transmitted by water exposures, but its persistence in water is not well understood. Loss of HuNoV infectivity in surface water was compared with persistence of intact HuNoV capsids and genome segments. Surface water from a freshwater creek was filter-sterilized, inoculated with HuNoV (GII.4) purified from stool, and incubated at 15 or 20 °C. We measured HuNoV infectivity via the human intestinal enteroid system and HuNoV persistence via reverse transcription-quantitative polymerase chain reaction assays without (genome segment persistence) or with (intact viral capsid persistence) enzymatic pretreatment to digest naked RNA. For infectious HuNoV, results ranged from no significant decay to a decay rate constant (

Indexed as

NorovirusWaterFresh WaterHumansVirus InactivationWatercapsid integritycreek watergenome integrityvirus

Identifiers

PMID36812385
PMCPMC9996820
OpenAlexW4321480802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.