ArticleScience translational medicine2023
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 50 citations in OpenAlex.
- Intratumoral androstene-3,17-dione defines breast cancer subtype and prognosis.EMBO molecular medicine · 2026Article
- Obesity-related Metabolic Dysfunction and Triple-negative Breast Cancer: Epidemiologic Signals, Mechanistic Pathways, and Opportunities for Prevention.Current obesity reports · 2026Review
- Molecular mechanisms and clinical impacts of sex differences in urologic cancers.Discover oncology · 2026Review
- Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity.Neoplasia (New York, N.Y.) · 2026Article
- The role of body mass index and tumor necrosis factor α in breast cancer development: a case-control study.Archives of medical science : AMS · 2026Article
- Genetic susceptibility shaped by biological state: beyond gene-environment interaction.Frontiers in genetics · 2026Review
- Breast Cancer Burden in BRICS Countries Attributable to Smoking, High Alcohol Use, High Body Mass Index, and Low Physical Activity, 1990-2021: Findings from the Global Burden of Disease 2021 and Mendelian Randomization.International journal of women's health · 2026Article
- Health Behaviors and Cancer Diagnosis Among Individuals with Pathogenic Variants Associated with Hereditary Breast and Ovarian Cancer or Lynch Syndrome.Journal of personalized medicine · 2025Article
- Insights into the molecular and genetic role of obesity in breast cancer pathogenesis.Cancer biology & therapy · 2025Review
- Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025Review
- Biomarkers of psychological stress are associated with increased susceptibility to the development of breast and prostate cancer in BRCA1/2 mutation carriers.British journal of cancer · 2025Article
- Distribution of age at natural menopause, age at menarche, menstrual cycle length, height and BMI in BRCA1 and BRCA2 pathogenic variant carriers and non-carriers: results from EMBRACE.Breast cancer research : BCR · 2025Article
- Significance of Midkine Signaling in Women's Cancers: Novel Biomarker and Therapeutic Target.International journal of molecular sciences · 2025Review
- Lepidium Sativum Extract Alleviates Reproductive and Developmental Toxicity in Polycystic Ovary Syndrome Induced by Letrozole and High-Fat Diet in Rats.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Comorbidity in Midlife and Cancer Outcomes.JAMA network open · 2025Article
- Adipokines: masterminds of metabolic inflammation.Nature reviews. Immunology · 2025Review
- A Novel Insight into the Role of Obesity-Related Adipokines in Ovarian Cancer-State-of-the-Art Review and Future Perspectives.International journal of molecular sciences · 2025Review
- Complement activation at the interface between adipocytes and cancer cells drives tumor progression.JCI insight · 2025Article
- Possible Prognostic Role of BMI Before Chemotherapy in the Outcomes of Women with Ovarian Cancer.Nutrients · 2025Article
Corrections and comments
- Commented on by
Authors and funding
28 authors at 6 institutions in 5 countries.
Priya BhardwajDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-8740-0143
Neil M IyengarDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-9773-5235
Heba ZahidDepartment of Medical Laboratory Technology, College of Applied Medical Science, Taibah University, Medina 42353, Saudi Arabia.ORCID 0000-0003-0131-8195
Katharine M CarterDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Dong Jun ByunCenter for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul 02792, Korea.
Man Ho ChoiCenter for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID 0000-0003-1017-1156
Qi SunComputational Biology Service Unit of Life Sciences Core Laboratories Center, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-6140-2204
Oleksandr SavenkovDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY 10065, USA.
Charalambia LoukaDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Catherine LiuDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-7103-6663
Phoebe PilocoDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-9671-9455
Monica AcostaDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-4202-7765
Rohan BarejaCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Olivier ElementoCaryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-8061-9617
Miguel ForondaDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Lukas E DowDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-7048-1418
Sofya OshchepkovaDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-6427-6063
Dilip D GiriDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Michael PollakDepartments of Medicine and Oncology, McGill University, Montreal, Canada.ORCID 0000-0003-3047-0604
Xi Kathy ZhouDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-8942-439X
Benjamin D HopkinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-7970-6430
Ashley M LaughneySandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-9435-953X
Melissa K FreyDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-6705-1211
Lora Hedrick EllensonDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Monica MorrowDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-4636-8313
Jason A SpectorLaboratory of Bioregenerative Medicine and Surgery, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-4202-7151
Lewis C CantleySandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-1298-7653
Kristy A BrownDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-3382-5546
Cornell University · USMemorial Sloan Kettering Cancer Center · USKorea Institute of Science and Technology · KRIcahn School of Medicine at Mount Sinai · USMcGill University · CATaibah University · SA
Funding
Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MInstitutional Career Development CoreKL2TR002385 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI YUAN-SHAN ZHU · 2017 to 2026
$13.3MRole of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2MObesity Increases Breast Cancer Penetrance in BRCA Mutation Carriers: A Role for Local and Systemic FactorsR01CA215797 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BROWN, KRISTY A. · 2017 to 2021
$2.6MMechanisms of obesity-induced breast epithelial cell DNA damage in BRCA mutation carriersF31CA236306 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BHARDWAJ, PRIYA · 2019 to 2021
$137kNCATS NIH HHS KL2 TR002385NCI NIH HHS F31 CA236306NCI NIH HHS R01 CA215797NCI NIH HHS R35 CA197588NIGMS NIH HHS T32 GM007739
Abstract
Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated BMI is a risk factor for women with a germline mutation in
Indexed as
Breast NeoplasmsMammary Glands, HumanAnimalsBRCA1 ProteinBRCA2 ProteinDNA DamageEpitheliumEstrogensFemaleGerm-Line MutationHumansLeptinMiceMutationObesityPhosphatidylinositol 3-KinasesBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanEstrogensLeptinPhosphatidylinositol 3-Kinases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.