ArticleScience advances2023
Biomolecular actuators for genetically selective acoustic manipulation of cells.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Real-time volumetric imaging of cells and molecules in deep tissues with Takoyaki ultrasound.Nature communications · 2026Article
- Reconfigurable Acoustofluidic Microvortices for Selective Microcargo Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Temporal gene regulation enables controlled expression of gas vesicles and preserves bacterial viability.Nature communications · 2025Article
- Enhancing Microparticle Separation Efficiency in Acoustofluidic Chips via Machine Learning and Numerical Modeling.Sensors (Basel, Switzerland) · 2025Article
- Dissipative Particle Dynamics Models of Encapsulated Microbubbles and Nanoscale Gas Vesicles for Biomedical Ultrasound Simulations.ACS applied nano materials · 2025Article
- Acoustic technologies for the orchestration of cellular functions for therapeutic applications.Science advances · 2025Review
- Recent Advances in Stimuli-Responsive Materials and Soft Robotic Actuators for Bioelectronic Medicine.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Acoustic percolation switches enable targeted drug delivery controlled by diagnostic ultrasound.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Imaging-guided deep tissue in vivo sound printing.Science (New York, N.Y.) · 2025Article
- Acoustofluidic bioassembly induced morphogenesis for therapeutic tissue fabrication.Nature communications · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches.Cells · 2025Review
- Advanced Strategies for Ultrasound Control and Applications in Sonogenetics and Gas Vesicle-Based Technologies: A Review.International journal of nanomedicine · 2025Review
- Pressure estimation of ultra-high frequency ultrasound using gas vesicles.The Journal of the Acoustical Society of America · 2024Article
- Control of myotube orientation using ultrasonication.Scientific reports · 2024Article
- Elucidating the assembly of gas vesicles by systematic protein-protein interaction analysis.The EMBO journal · 2024Article
- Physical-property-based patterning: simply engineering complex tissues.Trends in biotechnology · 2024Review
- 50-nm Gas-Filled Protein Nanostructures to Enable the Access of Lymphatic Cells by Ultrasound Technologies.Advanced materials (Deerfield Beach, Fla.) · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The ability to physically manipulate specific cells is critical for the fields of biomedicine, synthetic biology, and living materials. Ultrasound has the ability to manipulate cells with high spatiotemporal precision via acoustic radiation force (ARF). However, because most cells have similar acoustic properties, this capability is disconnected from cellular genetic programs. Here, we show that gas vesicles (GVs)-a unique class of gas-filled protein nanostructures-can serve as genetically encodable actuators for selective acoustic manipulation. Because of their lower density and higher compressibility relative to water, GVs experience strong ARF with opposite polarity to most other materials. When expressed inside cells, GVs invert the cells' acoustic contrast and amplify the magnitude of their ARF, allowing the cells to be selectively manipulated with sound waves based on their genotype. GVs provide a direct link between gene expression and acoustomechanical actuation, opening a paradigm for selective cellular control in a broad range of contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.