Evidence map›Paper›PMID 36812305›Full record

ArticleScience advances2023

Bioresorbable, wireless, and battery-free system for electrotherapy and impedance sensing at wound sites.

Joseph W Song, Hanjun Ryu, Wubin Bai, Zhaoqian Xie, Abraham Vázquez-Guardado, Khizar Nandoliya, Raudel Avila, Geumbee Lee, Zhen Song, Jihye Kim and 14 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
26.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Multi-Axis Stretchable Zippers for Personalized Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Article
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  18. Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 3 countries.

Joseph W SongDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-3506-6080
Hanjun RyuDepartment of Advanced Materials Engineering, Chung-Ang University, Anseong, Korea.ORCID 0000-0002-3268-9661
Wubin BaiDepartment of Applied Physical Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-2872-5559
Zhaoqian XieState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116023, P. R. China.ORCID 0000-0003-1320-817X
Abraham Vázquez-GuardadoQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-0648-5921
Khizar NandoliyaQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-6616-4388
Raudel AvilaDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
Geumbee LeeQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-0907-4092
Zhen SongState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116023, P. R. China.ORCID 0000-0002-0726-2455
Jihye KimQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Min-Kyu LeeQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-8770-585X
Yugang LiuCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-5304-3459
Mirae KimCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.
Huifeng WangCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, USA.
Yixin WuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-6315-4694
Hong-Joon YoonDepartment of Electronic Engineering, Gachon University, Seongnam 13120, Korea.ORCID 0000-0002-5668-3192
Sung Soo KwakCenter for Bionics of Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Korea.ORCID 0000-0002-2625-2471
Jaeho ShinQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-5280-3356
Kyeongha KwonDepartment of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Wei LuQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-1328-4471
Xuexian ChenAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871 China.
Yonggang HuangQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-0483-8359
Guillermo A AmeerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-6023-048X
John A RogersDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-3830-5980
Northwestern University · USDalian University of Technology · CNChung-Ang University · KRGachon University · KRKorea Advanced Institute of Science and Technology · KRKorea Institute of Science and Technology · KRPeking University · CNUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Telemetric Regenerative Bandage for Accelerating Wound HealingR01DK131302 · NIDDK · NORTHWESTERN UNIVERSITY · PI AMEER, GUILLERMO ANTONIO, ROGERS, JOHN · 2021 to 2025
$3.2M
NCI NIH HHS P30 CA060553NIDDK NIH HHS R01 DK131302
6 · The paper itself

Abstract

Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, with additional notable economic impacts. Inflammation associated with these wounds leads to abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed to support the healing process. This observation motivates the treatment of chronic wounds with electrical stimulation therapy, but practical engineering challenges, difficulties in removing stimulation hardware from the wound site, and absence of means to monitor the healing process create barriers to widespread clinical use. Here, we demonstrate a miniaturized wireless, battery-free bioresorbable electrotherapy system that overcomes these challenges. Studies based on a splinted diabetic mouse wound model confirm the efficacy for accelerated wound closure by guiding epithelial migration, modulating inflammation, and promoting vasculogenesis. Changes in the impedance provide means for tracking the healing process. The results demonstrate a simple and effective platform for wound site electrotherapy.

Indexed as

Diabetes MellitusElectric Stimulation TherapyAbsorbable ImplantsAnimalsDisease Models, AnimalElectric ImpedanceInflammationMiceWound Healing

Identifiers

PMID36812305
PMCPMC9946359
OpenAlexW4321481099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.