Evidence map›Paper›PMID 36812303›Full record

ArticleJournal of the American Chemical Society2023

Hollow Octadecameric Self-Assembly of Collagen-like Peptides.

Le Tracy Yu, Maria C Hancu, Mark A B Kreutzberger, Amy Henrickson, Borries Demeler, Edward H Egelman, Jeffrey D Hartgerink

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Pre-cuticle DPY-6 acts as a blueprint for aECM periodic organization inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. A Collagen Triple Helix without the Super Helical Twist.bioRxiv : the preprint server for biology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Autohydrolysis of Diglycine-Activated Succinic Esters Boosts Cellular Uptake.Angewandte Chemie (International ed. in English) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Le Tracy YuDepartment of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.ORCID 0000-0001-9904-6460
Maria C HancuDepartment of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.
Mark A B KreutzbergerDepartment of Biochemistry and Molecular Genetics, University of Virginia, Box 800733, Charlottesville, Virginia 22908, United States.
Amy HenricksonDepartment of Chemistry & Biochemistry, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada.ORCID 0000-0003-3266-5202
Borries DemelerDepartment of Chemistry & Biochemistry, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada.ORCID 0000-0002-2414-9518
Edward H EgelmanDepartment of Biochemistry and Molecular Genetics, University of Virginia, Box 800733, Charlottesville, Virginia 22908, United States.ORCID 0000-0003-4844-5212
Jeffrey D HartgerinkDepartment of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States.ORCID 0000-0002-3186-5395

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
Cryo-EM of Helical Protein and Nucleoprotein Polymers at Near Atomic ResolutionR35GM122510 · NIGMS · UNIVERSITY OF VIRGINIA · PI EDWARD H. EGELMAN · 2017 to 2026
$7.3M
Development of an UltraScan Meta-Scheduler for HPC Job SubmissionR01GM120600 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Emre H. Brookes, BORRIES DEMELER · 2016 to 2026
$3.6M
NCI NIH HHS P30 CA044579NIGMS NIH HHS R01 GM120600NIGMS NIH HHS R35 GM122510
6 · The paper itself

Abstract

The folding of collagen is a hierarchical process that starts with three peptides associating into the characteristic triple helical fold. Depending on the specific collagen in question, these triple helices then assemble into bundles reminiscent of α-helical coiled-coils. Unlike α-helices, however, the bundling of collagen triple helices is very poorly understood with almost no direct experimental data available. In order to shed light on this critical step of collagen hierarchical assembly, we have examined the collagenous region of complement component 1q. Thirteen synthetic peptides were prepared to dissect the critical regions allowing for its octadecameric self-assembly. We find that short peptides (under 40 amino acids) are able to self-assemble into specific (ABC)

Indexed as

CollagenPeptidesAmino Acid SequenceCryoelectron MicroscopyProtein Conformation, alpha-HelicalCollagenPeptides

Identifiers

PMID36812303
PMCPMC10131286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.