ArticlePloS one2023
In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Resonance Frequency Analysis and Clinical Outcomes in Implant Dentistry: A Systematic Review and Meta-Analysis.Clinical implant dentistry and related research · 2026Pooled it
- Reimagining Spinal Surgery at the Nanoscale: Smart Implants, Targeted Therapies, and Translational Challenges.Biology · 2026Review
- Biomimetic Surface Engineering Strategies for Enhanced Osseointegration and Peri-Implant Bone Regeneration: A Systematic Review.Biomimetics (Basel, Switzerland) · 2026Review
- Molecular Insights into the Synergistic Effect of Nano-Hydroxyapatite andJournal of functional biomaterials · 2026Article
- Surface Modification of Titanium Using Nano-Hydroxyapatite: A Comparative Microhardness Study.Cureus · 2026Article
- Temporal Dynamics and Uptake Mechanisms of Carbonated Hydroxyapatite Nanoparticles in Murine F‑OST Cells.ACS omega · 2026Article
- Biomechanical behavior of two different surface treatments on dental implants with healing chambers in osteoporotic rabbits: an experimental study.Scientific reports · 2025Article
- Nanofeatured Titanium Surfaces for Dental Implants: A Systematic Evaluation of Osseointegration.Antibiotics (Basel, Switzerland) · 2025Review
- In Vivo Evaluation of Laser-Textured Air Plasma in Osseointegration of Dental Implants.Materials (Basel, Switzerland) · 2025Article
- Controlling Sodium Titanate Crystal Size to Improve Wettability and Early Osseointegration of Titanium Implants: Insights from an Animal Model.Journal of functional biomaterials · 2025Article
- The Effect of Various Implant Coatings on Bone Formation and Cell Adhesion.Journal of pharmacy & bioallied sciences · 2025Article
- Histomorphometric and microtomographic evaluation of hydroxyapatite coated implants and L-PRF in over drilled bone sites in sheep.Scientific reports · 2025Article
- In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite.Journal of functional biomaterials · 2025Article
- Comparison Between Micro- and Micro-Nano Surface Texturization in the Initial Osseointegration Process: An Experimental In Vitro and In Vivo Preclinical Study.Bioengineering (Basel, Switzerland) · 2025Article
- Synthetic Nanopillars for Stimulating Osteoblast Activity and Osteointegration in Bone-Related Disorders.International journal of nanomedicine · 2025Review
- The Incorporation of Zinc into Hydroxyapatite and Its Influence on the Cellular Response to Biomaterials: A Systematic Review.Journal of functional biomaterials · 2024Review
- Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review.Molecules (Basel, Switzerland) · 2024Review
- In Vivo Biocompatibility Study on Functional Nanostructures Containing Bioactive Glass and Plant Extracts for Implantology.International journal of molecular sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis in vivo study, aimed to biomechanically, histomorphometrically and histologically evaluate an implant surface coated with nanostructured hydroxyapatite using the wet chemical process (biomimetic deposition of calcium phosphate coating) when compared to a dual acid-etching surface. MATERIAL AND
methodsTen sheep (2-4 years old) received 20 implants, 10 with nanostructured hydroxyapatite coating (HAnano), and 10 with dual acid-etching surface (DAA). The surfaces were characterized with scanning electron microscopy and energy dispersive spectroscopy; insertion torque values and resonance frequency analysis were measured to evaluate the primary stability of the implants. Bone-implant contact (BIC) and bone area fraction occupancy (BAFo) were evaluated 14 and 28 days after implant installation.
resultsThe HAnano and DAA groups showed no significant difference in insertion torque and resonance frequency analysis. The BIC and BAFo values increased significantly (p<0.05) over the experimental periods in both groups. This event was also observed in BIC value of HAnano group. The HAnano surface showed superior results compared to DAA after 28 days (BAFo, p = 0.007; BIC, p = 0.01).
conclusionThe results suggest that the HAnano surface favors bone formation when compared to the DAA surface after 28 days in low-density bone in sheep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.