Evidence map›Paper›PMID 36812155›Full record

ArticleJournal of proteome research2023

UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications.

Mo Awchi, Pablo Sinues, Alexandre N Datta, Diego García-Gómez, Kapil Dev Singh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mo AwchiUniversity Children's Hospital Basel, University of Basel, Spitalstrasse 33, 4056 Basel, Switzerland.
Pablo SinuesUniversity Children's Hospital Basel, University of Basel, Spitalstrasse 33, 4056 Basel, Switzerland.ORCID 0000-0001-5602-2880
Alexandre N DattaUniversity Children's Hospital Basel, University of Basel, Spitalstrasse 33, 4056 Basel, Switzerland.
Diego García-GómezDepartment of Analytical Chemistry, University of Salamanca, Plaza de los Caídos s/n, 37008 Salamanca, Spain.ORCID 0000-0001-5753-2962
Kapil Dev SinghUniversity Children's Hospital Basel, University of Basel, Spitalstrasse 33, 4056 Basel, Switzerland.ORCID 0000-0002-5682-0708
University of Basel · CHUniversidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-time breath analysis using secondary electrospray ionization coupled with high-resolution mass spectrometry is a fast and noninvasive method to access the metabolic state of a person. However, it lacks the ability to unequivocally assign mass spectral features to compounds due to the absence of chromatographic separation. This can be overcomed by using exhaled breath condensate and conventional liquid chromatography-mass spectrometry (LC-MS) systems. In this study, to the best of our knowledge, we confirm for the first time the presence of six amino acids (GABA, Oxo-Pro, Asp, Gln, Glu, and Tyr) previously reported to be involved in response to and side effects from antiseizure medications in exhaled breath condensate and by extension in exhaled human breath. Raw data are publicly available at MetaboLights with the accession number MTBLS6760.

Indexed as

Amino AcidsTandem Mass SpectrometryBreath TestsChromatography, High Pressure LiquidChromatography, LiquidHumansSpectrometry, Mass, Electrospray IonizationAmino Acidsamino acidscompound identificationexhaled breath condensatetandem mass spectrometryUHPLC

Identifiers

PMID36812155
PMCPMC9990125
OpenAlexW4321488164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.