Evidence map›Paper›PMID 36811861›Full record

Trial reportJAMA network open2023

Effects of Electroacupuncture for Opioid-Induced Constipation in Patients With Cancer in China: A Randomized Clinical Trial.

Weiming Wang, Yan Liu, Xiaofang Yang, Jianhua Sun, Zenghui Yue, Dianrong Lu, Kehua Zhou, Yuanjie Sun, Aihua Hou, Zhiwei Zang and 6 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA network open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03797586 (Effect of Electroacupuncture on Opioid-induced Constipation in Patients With Cancer), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03797586 nacompletednot on this map

Effect of Electroacupuncture on Opioid-induced Constipation in Patients With Cancer: Study Protocol for a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorGuang'anmen Hospital of China Academy of Chinese Medical SciencesRan2019 to 2021Enrolled100ConditionsOpioid-induced Constipation in Patients With CancerArmsElectroacupuncture group, Sham electroacupuncture group
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  6. Acupuncture for subthreshold depression: a randomized controlled trial.BMC complementary medicine and therapies · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 2 countries.

Weiming WangDepartment of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Yan LiuKey Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Xiaofang YangCollege of Acumox and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Jianhua SunDepartment of Acupuncture Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Zenghui YueCollege of Acupuncture and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Dianrong LuDepartment of Oncology, Wang Jing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Kehua ZhouDepartment of Hospital Medicine, ThedaCare Regional Medical Center-Appleton, Appleton, Wisconsin.
Yuanjie SunDepartment of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Aihua HouDepartment of Oncology, Yantai Hospital of Traditional Chinese Medicine, Yantai, China.
Zhiwei ZangDepartment of Acupuncture, Yantai Hospital of Traditional Chinese Medicine, Yantai, China.
Xiaoqing JinDepartment of Acupuncture, Zhejiang Hospital, Hangzhou, China.
Chao LiuCollege of Acumox and Tuina, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Yuhang WangDepartment of Acupuncture Rehabilitation, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Jinna YuDepartment of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Lili ZhuDepartment of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Zhishun LiuDepartment of Acupuncture and Moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNGuang’anmen Hospital · CNGuizhou University · CNNanjing University of Chinese Medicine · CNYantaishan Hospital · CNBeijing University of Chinese Medicine · CNHunan University of Traditional Chinese Medicine · CNTheda Clark Medical Center · USZhejiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Opioid-induced constipation (OIC) is prevalent among patients treated with opioids for cancer pain. Safe and effective therapies for OIC in patients with cancer remain an unmet need. Objective: To determine the efficacy of electroacupuncture (EA) for OIC in patients with cancer. Design, Setting, and Participants: This randomized clinical trial was conducted at 6 tertiary hospitals in China among 100 adult patients with cancer who were screened for OIC and enrolled between May 1, 2019, and December 11, 2021. Interventions: Patients were randomized to receive 24 sessions of EA or sham electroacupuncture (SA) over 8 weeks and then were followed up for 8 weeks after treatment. Main Outcomes and Measures: The primary outcome was the proportion of overall responders, defined as patients who had at least 3 spontaneous bowel movements (SBMs) per week and an increase of at least 1 SBM from baseline in the same week for at least 6 of the 8 weeks of the treatment period. All statistical analyses were based on the intention-to-treat principle. Results: A total of 100 patients (mean [SD] age, 64.4 [10.5] years; 56 men [56.0%]) underwent randomization; 50 were randomly assigned to each group. Among them, 44 of 50 patients (88.0%) in the EA group and 42 of 50 patients (84.0%) in the SA group received at least 20 (≥83.3%) sessions of treatment. The proportion of overall responders at week 8 was 40.1% (95% CI, 26.1%-54.1%) in the EA group and 9.0% (95% CI, 0.5%-17.4%) in the SA group (difference between groups, 31.1 percentage points [95% CI, 14.8-47.6 percentage points]; P < .001). Compared with SA, EA provided greater relief for most OIC symptoms and improved quality of life among patients with OIC. Electroacupuncture had no effects on cancer pain and its opioid treatment dosage. Electroacupuncture-related adverse events were rare, and, if any, all were mild and transient. Conclusions and Relevance: This randomized clinical trial found that 8-week EA treatment could increase weekly SBMs with a good safety profile and improve quality of life for the treatment of OIC. Electroacupuncture thus provided an alternative option for OIC in adult patients with cancer. Trial Registration: ClinicalTrials.gov Identifier: NCT03797586.

Indexed as

Cancer PainElectroacupunctureNeoplasmsOpioid-Induced ConstipationAdultAnalgesics, OpioidChinaConstipationHumansMaleMiddle AgedQuality of LifeAnalgesics, Opioid

Identifiers

PMID36811861
PMCPMC9947731
OpenAlexW4321491020

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.