Evidence map›Paper›PMID 36811771›Full record

ArticleApplied biochemistry and biotechnology2023

Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) P.G. Waterman.

Hermia Nalova Ikome, Alfred Ngenge Tamfu, Jean Pierre Abdou, Hugues Fouotsa, Pamela Kemda Nangmo, Fidèle Castro Weyepe Lah, Alembert Tiabou Tchinda, Ozgur Ceylan, Michel Frederich, Augustin Ephrem Nkengfack

Open access · greenAbstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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  7. Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Hermia Nalova IkomeDepartment of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.
Alfred Ngenge TamfuSchool of Chemical Engineering and Mineral Industries, University of Ngaoundere, P.O. Box 454, Ngaoundere, Cameroon. macntamfu@yahoo.co.uk.ORCID http://orcid.org/0000-0001-6683-3337
Jean Pierre AbdouDepartment of Chemistry, Faculty of Science, University of Ngaoundere, P.O. Box 454, Ngaondere, Cameroon.
Hugues FouotsaDepartment of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.
Pamela Kemda NangmoDepartment of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.
Fidèle Castro Weyepe LahDepartment of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.
Alembert Tiabou TchindaLaboratory of Phytochemistry, Center for Studies on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 13033, Yaounde, Cameroon. talembert@gmail.com.
Ozgur CeylanFood Quality Control and Analysis Program, Ula Ali Kocman Vocational School, Mugla Sitki Kocman University, 48147, Mugla, Turkey.
Michel FrederichLaboratory of Pharmacognosy, Center for Interdisciplinary Research on Medicine, CIRM, University of Liege, 4000, Liege, Belgium.
Augustin Ephrem NkengfackDepartment of Organic Chemistry, University of Yaounde I, P.O. Box 812, Yaoundé, Cameroon.
Université de Yaoundé I · CMUniversity of Ngaoundéré · CMInstitut de Recherches Médicales et d’Etudes des Plantes Médicinales · CMMuğla University · TRUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial resistance is facilitated by biofilm formation and quorum-sensing mediated processes. In this work, the stem bark (ZM) and fruit extracts (ZMFT) of Zanthoxylum gilletii were subjected to column chromatography and afforded lupeol (1), 2,3-epoxy-6,7-methylenedioxyconiferyl alcohol (3), nitidine chloride (4), nitidine (7), sucrose (6) and sitosterol-β-D-glucopyranoside (2). The compounds were characterized using MS and NMR spectral data. The samples were evaluated for antimicrobial, antibiofilm and anti-quorum sensing activities. Highest antimicrobial activity was exhibited by compounds 3, 4 and 7 against Staphylococcus aureus (MIC 200 µg/mL), compounds 3 and 4 against Escherichia coli (MIC = 100 µg/mL) and compounds 4 and 7 against Candida albicans (MIC = 50 µg/mL). At MIC and sub-MIC concentrations, all samples inhibited biofilm formation by pathogens and violacein production in C. violaceum CV12472 except compound 6. Good disruption of QS-sensing in C. violaceum revealed by inhibition zone diameters were exhibited by compounds 3 (11.5 ± 0.5 mm), 4 (12.5 ± 1.5 mm), 5 (15.0 ± 0.8 mm), 7 (12.0 ± 1.5 mm) as well as the crude extracts from stem barks (16.5 ± 1.2 mm) and seeds (13.0 ± 1.4 mm). The profound inhibition of quorum sensing mediated processes in test pathogens by compounds 3, 4, 5 and 7 suggests the methylenedioxy- group that these compounds possess as the possible pharmacophore.

Indexed as

Anti-Infective AgentsZanthoxylumAnti-Bacterial AgentsBacteriaBiofilmsPlant ExtractsAnti-Bacterial AgentsAnti-Infective AgentsPlant ExtractsAntibiofilmAntimicrobial activityAnti-quorum sensingSecondary metabolitesZanthoxylum gilletii

Identifiers

PMID36811771
OpenAlexW4321487804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.