Effect of convalescent plasma transfusion on outcomes of coronavirus disease 2019: a meta-analysis with trial sequential analysis.

Sameh M Hakim, Ghosoun M A Chikhouni, Mona A Ammar, Akram M Amer

Open access · hybridAbstract readMeta-AnalysisReview

In one paragraph

Synthesis in Journal of anesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 43% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sameh M HakimDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, 15 Gamal Noah Street, Almaza, Heliopolis, Cairo, 11341, Egypt. hakimsm@med.asu.edu.eg.ORCID 0000-0003-1900-0353

Ghosoun M A ChikhouniDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, 15 Gamal Noah Street, Almaza, Heliopolis, Cairo, 11341, Egypt.

Mona A AmmarDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, 15 Gamal Noah Street, Almaza, Heliopolis, Cairo, 11341, Egypt.

Akram M AmerDepartment of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, 15 Gamal Noah Street, Almaza, Heliopolis, Cairo, 11341, Egypt.

Ain Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this review was to update evidence for benefit of convalescent plasma transfusion (CPT) in patients with coronavirus disease 2019 (COVID-19). Databases were searched for randomized controlled trials (RCT) comparing CPT plus standard treatment versus standard treatment only in adults with COVID-19. Primary outcome measures were mortality and need for invasive mechanical ventilation (IMV). Twenty-Six RCT involving 19,816 patients were included in meta-analysis for mortality. Quantitative synthesis showed no statistically significant benefit of adding CPT to standard treatment (RR = 0.97, 95% CI = 0.92 to 1.02) with unimportant heterogeneity (Q(25) = 26.48, p = .38, I

Indexed as

COVID-19AdultCOVID-19 SerotherapyHumansRespiration, ArtificialSARS-CoV-2Convalescent plasmaCoronavirus disease 2019COVID-19CPCPTNovel coronavirusSARS-COV-2Severe acute respiratory syndrome coronavirus 2Transfusion

Identifiers

PMID36811668

DOI10.1186/s12874-017-0315-7

PMCPMC9944423

OpenAlexW4321487861

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.