Evidence map›Paper›PMID 36811273›Full record

ArticleNeuropsychopharmacology reports2023

Management of unspecified anxiety disorder: Expert consensus.

Hitoshi Sakurai, Ken Inada, Yumi Aoki, Masahiro Takeshima, Kenya Ie, Morito Kise, Eriko Yoshida, Takashi Tsuboi, Hisashi Yamada, Hikaru Hori and 5 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Neuropsychopharmacology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Clinical practice for unspecified anxiety disorder in primary care.PCN reports : psychiatry and clinical neurosciences · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Hitoshi SakuraiDepartment of Neuropsychiatry, Kyorin University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-5399-7946
Ken InadaDepartment of Psychiatry, School of Medicine, Kitasato University, Kanagawa, Japan.ORCID 0000-0002-3073-4588
Yumi AokiPsychiatric and Mental Health Nursing, St. Luke's International University, Tokyo, Japan.ORCID 0000-0002-2674-0707
Masahiro TakeshimaDepartment of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.
Kenya IeDivision of General Internal Medicine, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.
Morito KiseCentre for Family Medicine Development, Japanese Health and Welfare Co-operative Federation, Tokyo, Japan.
Eriko YoshidaDepartment of General Internal Medicine, Kawasaki Kyodo Hospital, Kawasaki Health Cooperative Association, Kanagawa, Japan.
Takashi TsuboiDepartment of Neuropsychiatry, Kyorin University Faculty of Medicine, Tokyo, Japan.
Hisashi YamadaDepartment of Neuropsychiatry, Hyogo Medicial University, Hyogo, Japan.
Hikaru HoriDepartment of Psychiatry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Yasushi InadaMedical corporation YUJIN-KAI Inada Clinic, Osaka, Japan.
Eiji ShimizuResearch Center for Child Mental Development, Chiba University, Chiba, Japan.
Kazuo MishimaDepartment of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.
Koichiro WatanabeDepartment of Neuropsychiatry, Kyorin University Faculty of Medicine, Tokyo, Japan.
Yoshikazu TakaesuDepartment of Neuropsychiatry, Kyorin University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-9169-3249
Kyorin University · JPAkita University · JPChiba University · JPFamily Inada (Japan) · JPFukuoka University · JPHyogo University · JPKawasaki Hospital · JPKitasato University · JPMinistry of Health Labour and Welfare · JPSt. Luke's International University · JPSt. Marianna University School of Medicine · JP

Funding

Ministry of Health, Labor and Welfare of Japan 21GC1016
6 · The paper itself

Abstract

aimsTreatment guidelines with respect to unspecified anxiety disorder have not been published. The aim of this study was to develop a consensus among field experts on the management of unspecified anxiety disorder.

methodsExperts were asked to evaluate treatment choices based on eight clinical questions concerning unspecified anxiety disorder using a nine-point Likert scale (1 = "disagree" to 9 = "agree"). According to the responses from 119 experts, the choices were categorized into first-, second-, and third-line recommendations.

resultsBenzodiazepine anxiolytic use was not categorized as a first-line recommendation for the primary treatment of unspecified anxiety disorder, whereas multiple nonpharmacological treatment strategies, including coping strategies (7.9 ± 1.4), psychoeducation for anxiety (7.9 ± 1.4), lifestyle changes (7.8 ± 1.5), and relaxation techniques (7.4 ± 1.8), were categorized as first-line recommendations. Various treatment strategies were categorized as first-line recommendations when a benzodiazepine anxiolytic drug did not improve anxiety symptoms, that is, differential diagnosis (8.2 ± 1.4), psychoeducation for anxiety (8.0 ± 1.5), coping strategies (7.8 ± 1.5), lifestyle changes (7.8 ± 1.5), relaxation techniques (7.2 ± 1.9), and switching to selective serotonin reuptake inhibitors (SSRIs) (7.0 ± 1.8). These strategies were also highly endorsed when tapering the dosage of or discontinuing benzodiazepine anxiolytic drugs. There was no first-line recommendation regarding excusable reasons for continuing benzodiazepine anxiolytics.

conclusionsThe field experts recommend that benzodiazepine anxiolytics should not be used as a first-line option for patients with unspecified anxiety disorder. Instead, several nonpharmacological interventions and switching to SSRIs were endorsed for the primary treatment of unspecified anxiety disorder and as alternatives to benzodiazepine anxiolytics.

Indexed as

Anti-Anxiety AgentsAnxiety DisordersBenzodiazepinesConsensusHumansSelective Serotonin Reuptake InhibitorsAnti-Anxiety AgentsBenzodiazepinesSelective Serotonin Reuptake Inhibitorsanxiolyticsbenzodiazepineexpert consensusunspecified anxiety disorder

Identifiers

PMID36811273
PMCPMC10275278
OpenAlexW4321499192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.