Evidence map›Paper›PMID 36811091›Full record

ArticlebioRxiv : the preprint server for biology2023

Extracellular communication between brain cells through functional transfer of Cre mRNA.

David Rufino-Ramos, Kevin Leandro, Pedro R L Perdigão, Killian O'Brien, Maria Manuel Pinto, Magda M Santana, Thomas S van Solinge, Shadi Mahjoum, Xandra O Breakefield, Koen Breyne and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

David Rufino-RamosCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Kevin LeandroCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Pedro R L PerdigãoCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Killian O'BrienMolecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Maria Manuel PintoCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Magda M SantanaCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Thomas S van SolingeMolecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Shadi MahjoumMolecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Xandra O BreakefieldMolecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Koen BreyneMolecular Neurogenetics Unit, Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Luís Pereira de AlmeidaCNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
The power of extracellular vesicles in glioblastomaR35CA232103 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS · 2018 to 2024
$6.9M
NCI NIH HHS P01 CA069246NCI NIH HHS R35 CA232103
6 · The paper itself

Abstract

In the central nervous system (CNS), the crosstalk between neural cells is mediated by extracellular mechanisms, including brain-derived extracellular vesicles (bdEVs). To study endogenous communication across the brain and periphery, we explored Cre-mediated DNA recombination to permanently record the functional uptake of bdEVs cargo overtime. To elucidate functional cargo transfer within the brain at physiological levels, we promoted the continuous secretion of physiological levels of neural bdEVs containing Cre mRNA from a localized region in the brain by

Indexed as

braincentral nervous systemCre-LoxPexosomesexRNAextracellular communicationextracellular vesiclesNanoluc

Identifiers

PMID36811091
PMCPMC9942248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.