ReviewNature reviews psychology2023
Understanding clinical fear and anxiety through the lens of human fear conditioning.
Review in Nature reviews psychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Reducing distress during vaccine injections: 2026 clinical practice guideline update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Guideline
- The effect of social anxiety on threat acquisition and extinction: a systematic review and meta-analysis.PeerJ · 2024Pooled it
- Attentional processing in individual anxiety: Electrocortical correlates of threat- and safety-related declarative memory formation.Cognitive, affective & behavioral neuroscience · 2026Article
- Severe PTSD symptoms magnify episodic memory-encoding deficits and amygdala-ACC attenuation during unpredictable threat in male combat veterans.Molecular psychiatry · 2026Article
- From Parents to Teens: Unpacking the Anxiety Transmission Pathway in Parent-Adolescent Dyads through Parent-Adolescent Relationships and Academic Stress.The Psychiatric quarterly · 2026Article
- When time matters: generalization gradients in delay and trace conditioning procedures.Learning & behavior · 2026Article
- A ventral striatal learning signal reflecting individual differences in the success of fear extinction.Molecular psychiatry · 2026Article
- Anxiety disorders: a cross-sectional study of clinical and biological associations.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Model-Free and Model-Based Learning in Human Fear Conditioning.Psychophysiology · 2026Article
- Aberrant Fear: Biological Underpinnings Relevant to Psychosis, Antipsychotic Drugs, and Psychotherapeutic Treatments, a Translational Approach.International journal of molecular sciences · 2026Review
- Imagery-based fear conditioning enhances the late positive potential.Cognitive, affective & behavioral neuroscience · 2026Article
- Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice.iScience · 2026Article
- Threat Conditioning Prior to Cocaine or Sucrose Exposure Alters Reward-Seeking Behavior in a Sex-Dependent Manner.Psychiatry international · 2026Article
- Psychophysiological Outcome Responses in Human Pavlovian Fear Conditioning: A Prediction Error Analysis.Psychophysiology · 2026Article
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- From Struggling (With) Screening Tests to Mouse Models of Depression-Relevant Neurobehavioral States.Current protocols · 2026Article
- High Trait Anxiety Attenuates EML Amplitude Following Uncertainty Resolution: ERP Evidence of Impaired Emotional Disengagement.Psychology research and behavior management · 2026Article
- Acute psilocybin or ethocybin leads to a sustained increase in Pavlovian aversion memory in male mice.Frontiers in pharmacology · 2026Article
- Representational dynamics during extinction of fear memories in the human brain.Nature human behaviour · 2026Article
- Direct and indirect associations of hypochondriasis with suicidality in psychiatric outpatients: mediating roles of anxiety and depression.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear is an adaptive emotion that mobilizes defensive resources upon confrontation with danger. However, fear becomes maladaptive and can give rise to the development of clinical anxiety when it exceeds the degree of threat, generalizes broadly across stimuli and contexts, persists after the danger is gone or promotes excessive avoidance behaviour. Pavlovian fear conditioning has been the prime research instrument that has led to substantial progress in understanding the multi-faceted psychological and neurobiological mechanisms of fear in past decades. In this Perspective, we suggest that fruitful use of Pavlovian fear conditioning as a laboratory model of clinical anxiety requires moving beyond the study of fear acquisition to associated fear conditioning phenomena: fear extinction, generalization of conditioned fear and fearful avoidance. Understanding individual differences in each of these phenomena, not only in isolation but also in how they interact, will further strengthen the external validity of the fear conditioning model as a tool with which to study maladaptive fear as it manifests in clinical anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.