Evidence map›Paper›PMID 36810879›Full record

ArticleScientific reports2023

The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses.

Marinus Toman, John Joseph Wade, Alexei Verkhratsky, Mark Dallas, Angela Bithell, Bronac Flanagan, Jim Harkin, Liam McDaid

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Early Life Injury Alters Spinal Astrocyte Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Marinus TomanComputational Neuroscience and Neuromorphic Engineering Team, Intelligent Systems Research Centre, Ulster University, Northland Road, Derry, BT48 7JL, UK. m.toman@ulster.ac.uk.
John Joseph WadeComputational Neuroscience and Neuromorphic Engineering Team, Intelligent Systems Research Centre, Ulster University, Northland Road, Derry, BT48 7JL, UK.
Alexei VerkhratskyFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Mark DallasReading School of Pharmacy, University of Reading, Reading, UK.
Angela BithellReading School of Pharmacy, University of Reading, Reading, UK.
Bronac FlanaganComputational Neuroscience and Neuromorphic Engineering Team, Intelligent Systems Research Centre, Ulster University, Northland Road, Derry, BT48 7JL, UK.
Jim HarkinComputational Neuroscience and Neuromorphic Engineering Team, Intelligent Systems Research Centre, Ulster University, Northland Road, Derry, BT48 7JL, UK.
Liam McDaidComputational Neuroscience and Neuromorphic Engineering Team, Intelligent Systems Research Centre, Ulster University, Northland Road, Derry, BT48 7JL, UK.
University of Ulster · GBUniversity of Reading · GBState Research Institute Centre for Innovative Medicine · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes display a highly complex, spongiform morphology, with their fine terminal processes (leaflets) exercising dynamic degrees of synaptic coverage, from touching and surrounding the synapse to being retracted from the synaptic region. In this paper, a computational model is used to reveal the effect of the astrocyte-synapse spatial relationship on ionic homeostasis. Specifically, our model predicts that varying degrees of astrocyte leaflet coverage influences concentrations of K

Indexed as

AstrocytesSynapsesCalcium SignalingGlutamic AcidHomeostasisGlutamic Acid

Identifiers

PMID36810879
PMCPMC9944253
OpenAlexW4321446766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.