Evidence map›Paper›PMID 36810829›Full record

ArticleProtein science : a publication of the Protein Society2023

Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A.

A Díaz Casas, J J Cordoba, B J Ferrer, S Balakrishnan, J E Wurm, B Pastrana-Ríos, W J Chazin

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Aquaporin-0-protein interactions elucidated by crosslinking mass spectrometry.Biochemical and biophysical research communications · 2024
    Article
  2. Review
  3. Binding by calmodulin is coupled to transient unfolding of the third FF domain of Prp40A.Protein science : a publication of the Protein Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

A Díaz CasasDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-9470-6666
J J CordobaDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.
B J FerrerDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.
S BalakrishnanDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.
J E WurmChemical and Physical Biology Graduate Program, Vanderbilt University, Nashville, Tennessee, USA.
B Pastrana-RíosDepartment of Chemistry, University of Puerto Rico, Mayagüez Campus, Mayagüez, Puerto Rico, USA.
W J ChazinDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-2180-0790
Vanderbilt University · USUniversity of Puerto Rico-Mayaguez · PR

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
MOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9M
Structural Biology of Multi-Domain Proteins and Multi-Protein Machinery in DNA Replication and RepairR35GM118089 · NIGMS · VANDERBILT UNIVERSITY · PI WALTER J. CHAZIN · 2016 to 2026
$4.9M
TRAINING PROGRAM IN ION CHANNEL AND TRANSPORTER BIOLOGYT32NS007491 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S. · 2001 to 2020
$4.1M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
Console upgrades for biological NMR spectrometersS10RR025677 · NCRR · VANDERBILT UNIVERSITY · PI SANDERS, CHARLES R · 2009 to 2009
$460k
Interactions of intracellular calcium sensors with the pre-mRNA splicing factor Prp40F32GM136173 · NIGMS · VANDERBILT UNIVERSITY · PI DIAZ-CASAS, ADALBERTO · 2020 to 2021
$109k
NCI NIH HHS P30 CA068485NCRR NIH HHS S10 RR025677NIGMS NIH HHS F32 GM136173NIGMS NIH HHS F32GM136173NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM118089NIGMS NIH HHS R35GM118089NIGMS NIH HHS T32 GM008320NIGMS NIH HHS T32NS007491NIH HHS S10 OD018483NINDS NIH HHS T32 NS007491
6 · The paper itself

Abstract

Human pre-mRNA processing protein 40 homolog A (hPrp40A) is a splicing factor that interacts with the Huntington's disease protein huntingtin (Htt). Evidence has accumulated that both Htt and hPrp40A are modulated by the intracellular Ca

Indexed as

CalmodulinMolecular Dynamics SimulationBinding SitesCalciumHumansProtein BindingScattering, Small AngleX-Ray DiffractionCalciumCalmodulincalmodulinFF domainisothermal titration calorimetryNMRPrp40small angle X-ray scattering

Identifiers

PMID36810829
PMCPMC10022492
OpenAlexW4321499643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.