Evidence map›Paper›PMID 36810677›Full record

ArticleCalcified tissue international2023

Surgical Management and Denosumab for Aneurysmal Bone Cysts of the Spine in an Australian Tertiary Paediatric Centre.

Joel A Vanderniet, Dionysios Tsinas, Christie-Lee Wall, Christian M Girgis, Kevin London, Corinne Keane, Julie Briody, Sally Hibbert, Myra Poon, Bhavna Padhye and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Calcified tissue international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Tumors and infections of the growing spine.Journal of children's orthopaedics · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Joel A VandernietInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia. joel.vanderniet@health.nsw.gov.au.ORCID 0000-0002-7063-6667
Dionysios Tsinas *Department of Orthopaedics, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Christie-Lee WallInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia.
Christian M GirgisFaculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Kevin LondonDepartment of Nuclear Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Corinne KeaneDepartment of Orthopaedics, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Julie BriodyDepartment of Nuclear Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Sally HibbertDepartment of Dentistry, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Myra PoonInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia.
Bhavna PadhyeFaculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Andrew BigginInstitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, Sydney, NSW, 2145, Australia.
Luciano Dalla-PozzaFaculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Randolph J GrayDepartment of Orthopaedics, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Craig F MunnsChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
Children's Hospital at Westmead · AUThe University of Sydney · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneurysmal bone cysts (ABC) are rare osteolytic, benign but often locally aggressive tumours of the long bones or vertebrae. For spinal ABC, surgical management, embolisation or sclerotherapy alone often carry high morbidity and/or high recurrence rates. Interruption of receptor activator of nuclear factor-kappa B ligand (RANKL) signalling holds promise as an effective therapeutic strategy for these tumours. We aimed to review the approach to surgical management and evaluate the efficacy and safety of denosumab for ABC of the spine in children. Retrospective review of 7 patients treated with denosumab using a standardised protocol for ABC of the spine in a tertiary paediatric centre. Surgical intervention was only conducted if there was spinal instability or significant neurological impairment. Denosumab 70 mg/m

Indexed as

Bone Cysts, AneurysmalBone Density Conservation AgentsHypercalcemiaAustraliaChildDenosumabHumansSpineBone Density Conservation AgentsDenosumabEmbolisationHypercalcemiaHypocalcemiaPET/CTSclerotherapy

Identifiers

PMID36810677
OpenAlexW4321435326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.