Evidence map›Paper›PMID 36810470›Full record

ArticleNeurology international2023

Prediction of Poor Outcome after Successful Thrombectomy in Patients with Severe Acute Ischemic Stroke: A Pilot Retrospective Study.

Burak B Ozkara, Mert Karabacak, Apoorva Kotha, Alperen Aslan, Omar Hamam, Namratha Edpuganti, Meisam Hoseinyazdi, Richard Wang, Brian C Cristiano, Vivek S Yedavalli

Abstract read
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In one paragraph

Article in Neurology international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Burak B OzkaraDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA.ORCID 0000-0002-8769-3342
Mert KarabacakDepartment of Neurosurgery, Mount Sinai Health System, 1468 Madison Avenue, New York, NY 10029, USA.ORCID 0000-0002-9263-9893
Apoorva KothaRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.
Alperen AslanRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.
Omar HamamRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.
Namratha EdpugantiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.
Meisam HoseinyazdiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.ORCID 0000-0002-4051-2946
Richard WangRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.ORCID 0000-0003-3442-0559
Brian C CristianoDepartment of Interventional Neuroradiology, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.
Vivek S YedavalliRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA.ORCID 0000-0002-2450-4014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several baseline hematologic and metabolic laboratory parameters have been linked to acute ischemic stroke (AIS) clinical outcomes in patients who successfully recanalized. However, no study has directly investigated these relationships within the severe stroke subgroup. The goal of this study is to identify potential predictive clinical, lab, and radiographic biomarkers in patients who present with severe AIS due to large vessel occlusion and have been successfully treated with mechanical thrombectomy. This single-center, retrospective study included patients who experienced AIS secondary to large vessel occlusion with an initial NIHSS score ≥ 21 and were recanalized successfully with mechanical thrombectomy. Retrospectively, demographic, clinical, and radiologic data from electronic medical records were extracted, and laboratory baseline parameters were obtained from emergency department records. The clinical outcome was defined as the modified Rankin Scale (mRS) score at 90 days, which was dichotomized into favorable functional outcome (mRS 0-3) or unfavorable functional outcome (mRS 4-6). Multivariate logistic regression was used to build predictive models. A total of 53 patients were included. There were 26 patients in the favorable outcome group and 27 in the unfavorable outcome group. Age and platelet count (PC) were found to be predictors of unfavorable outcomes in the multivariate logistic regression analysis. The areas under the receiver operating characteristic (ROC) curve of models 1 (age only model), 2 (PC only model), and 3 (age and PC model) were 0.71, 0.68, and 0.79, respectively. This is the first study to reveal that elevated PC is an independent predictor of unfavorable outcomes in this specialized group.

Indexed as

acute ischemic strokemechanical thrombectomyplatelet countprognosis

Identifiers

PMID36810470
PMCPMC9944107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.