ArticleArchives of disease in childhood. Fetal and neonatal edition2023
Two-year outcomes following a randomised platelet transfusion trial in preterm infants.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Platelet transfusion thresholds for thrombocytopenic infants.The Cochrane database of systematic reviews · 2026Pooled it
- Optimizing platelet transfusion thresholds in preterm infants: a systematic review and narrative synthesis of impacts on survival and neurodevelopment.Blood transfusion = Trasfusione del sanguePooled it
- Heterogeneity of Critical Organ Dysfunction During Late-Onset Bacteremia in Preterm Infants.JAMA network open · 2026Observational
- Redefining neonatal thrombocytopenia: an evidence-based approach, improved by the refineR algorithm.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Embracing complexity in transfusion research.Vox sanguinis · 2026Review
- Neonatal platelets differentiate monocytes to a myeloid-derived suppressor cell phenotype.Blood · 2026Article
- Association of blood component transfusions with neurodevelopmental impairment in preterm infants by gestational age.Pediatric research · 2026Article
- [Anesthesia in neonates and preterm infants : Current knowledge on ventilation, circulation and transfusion].Die Anaesthesiologie · 2026Review
- Understanding the effects of platelet transfusions in neonates.Pediatric research · 2026Article
- Decreasing packed red blood cell (pRBC) transfusions in neonates through quality improvement.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Designing and implementing a clinical decision support tool to improve compliance with NICU transfusions.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature.Acta anaesthesiologica Scandinavica · 2026Review
- Platelet Transfusion Practices and Outcomes in Neonates and Children.JAMA network open · 2026Article
- An improvement project standardizing low prophylactic platelet transfusion dosing for infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Development and implementation of restrictive platelet transfusion thresholds in a neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Using a lower platelet transfusion threshold: translating evidence into practice.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Observational
- Unveiling the Hemostatic Signature of Prematurity: A Prospective Rotational Thromboelastometry-Based Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Platelet transfusion practice in the intensive care unit: the Nine-I international platelet transfusion survey.Annals of intensive care · 2025Article
- Forty-eight-hour cold-stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures.Vox sanguinis · 2025Article
Corrections and comments
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Authors and funding
23 authors at 12 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAssess mortality and neurodevelopmental outcomes at 2 years of corrected age in children who participated in the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion - 2/Management of Thrombocytopenia in Special Subgroup) study, which reported that a higher platelet transfusion threshold was associated with significantly increased mortality or major bleeding compared to a lower one.
designRandomised clinical trial, enrolling from June 2011 to August 2017. Follow-up was complete by January 2020. Caregivers were not blinded; however, outcome assessors were blinded to treatment group.
setting43 level II/III/IV neonatal intensive care units (NICUs) across UK, Netherlands and Ireland. PATIENTS: 660 infants born at less than 34 weeks' gestation with platelet counts less than 50×10
interventionsInfants were randomised to undergo a platelet transfusion at platelet count thresholds of 50×10 MAIN OUTCOMES MEASURES: Our prespecified long-term follow-up outcome was a composite of death or neurodevelopmental impairment (developmental delay, cerebral palsy, seizure disorder, profound hearing or vision loss) at 2 years of corrected age.
resultsFollow-up data were available for 601 of 653 (92%) eligible participants. Of the 296 infants assigned to the higher threshold group, 147 (50%) died or survived with neurodevelopmental impairment, as compared with 120 (39%) of 305 infants assigned to the lower threshold group (OR 1.54, 95% CI 1.09 to 2.17, p=0.017).
conclusionsInfants randomised to a higher platelet transfusion threshold of 50×10 TRIAL REGISTRATION NUMBER: ISRCTN87736839.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.