Evidence map›Paper›PMID 36810306›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Action selection in early stages of psychosis: an active inference approach.

Franziska Knolle, Elisabeth Sterner, Michael Moutoussis, Rick A Adams, Juliet D Griffin, Joost Haarsma, Hilde Taverne, Ian M Goodyer, Paul C Fletcher, Graham K Murray and 1 more

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In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Naturalistic computational psychiatry: How to get there?Journal of psychiatry & neuroscience : JPN
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Franziska Knolle *From the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray) franziska.knolle@tum.de.
Elisabeth Sterner *From the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Michael MoutoussisFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Rick A AdamsFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Juliet D GriffinFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Joost HaarsmaFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Hilde TaverneFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Ian M GoodyerFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Paul C FletcherFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
Graham K MurrayFrom the Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (Knolle, Sterner); the Department of Psychiatry, University of Cambridge, Cambridge, UK (Knolle, Griffin, Taverne, Goodyer, Fletcher, Murray); the Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, London, UK (Moutoussis, Adams); the Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK (Adams); the Wellcome Centre for Human Neuroimaging, University College London, London, UK (Haarsma); the University of Amsterdam, Amsterdam, NL (Taverne); Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK (Goodyer, Fletcher); Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (Murray).
NSPN Consortium

Funding

Wellcome Trust 095844/Z/11/Z
6 · The paper itself

Abstract

backgroundTo interact successfully with their environment, humans need to build a model to make sense of noisy and ambiguous inputs. An inaccurate model, as suggested to be the case for people with psychosis, disturbs optimal action selection. Recent computational models, such as active inference, have emphasized the importance of action selection, treating it as a key part of the inferential process. Based on an active inference framework, we sought to evaluate previous knowledge and belief precision in an action-based task, given that alterations in these parameters have been linked to the development of psychotic symptoms. We further sought to determine whether task performance and modelling parameters would be suitable for classification of patients and controls.

methodsTwenty-three individuals with an at-risk mental state, 26 patients with first-episode psychosis and 31 controls completed a probabilistic task in which action choice (go/no-go) was dissociated from outcome valence (gain or loss). We evaluated group differences in performance and active inference model parameters and performed receiver operating characteristic (ROC) analyses to assess group classification.

resultsWe found reduced overall performance in patients with psychosis. Active inference modelling revealed that patients showed increased forgetting, reduced confidence in policy selection and less optimal general choice behaviour, with poorer action-state associations. Importantly, ROC analysis showed fair-to-good classification performance for all groups, when combining modelling parameters and performance measures. LIMITATIONS: The sample size is moderate.

conclusionActive inference modelling of this task provides further explanation for dysfunctional mechanisms underlying decision-making in psychosis and may be relevant for future research on the development of biomarkers for early identification of psychosis.

Indexed as

Choice BehaviorPsychotic DisordersHumansModels, PsychologicalTask Performance and Analysis

Identifiers

PMID36810306
PMCPMC9949875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.