Evidence map›Paper›PMID 36810158›Full record

ArticleeLife2023

Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in

Andrew I Wong, Tiago Beites, Kyle A Planck, Rachael A Fieweger, Kathryn A Eckartt, Shuqi Li, Nicholas C Poulton, Brian C VanderVen, Kyu Y Rhee, Dirk Schnappinger and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. eLife · 2024
    Article
  7. Review
  8. Metabolic Rewiring ofMetabolites · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism inAntimicrobial agents and chemotherapy · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Andrew I WongLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, United States.
Tiago BeitesDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, United States.
Kyle A PlanckDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, United States.
Rachael A FiewegerDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, United States.
Kathryn A EckarttLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, United States.
Shuqi LiLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, United States.ORCID 0000-0002-8133-6838
Nicholas C PoultonLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, United States.
Brian C VanderVenDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, United States.ORCID 0000-0003-3655-4390
Kyu Y RheeDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, United States.
Dirk SchnappingerDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, United States.
Sabine EhrtDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, United States.ORCID 0000-0002-7951-2310
Jeremy RockLaboratory of Host-Pathogen Biology, The Rockefeller University, New York, United States.ORCID 0000-0002-9310-951X
Cornell University · USRockefeller University · US

Funding

Surviving evolution: Short-term adaptations for fitnessP01AI143575 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SABINE EHRT · 2020 to 2026
$18.2M
Study of M. tuberculosis under human host selection to identify virulence and barrier lipids (Project 1)U19AI162584 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2021 to 2025
$13.5M
Towards a molecular understanding of persistent tuberculosis infectionDP2AI144850 · NIAID · ROCKEFELLER UNIVERSITY · PI ROCK, JEREMY MICHAEL · 2018 to 2018
$2.5M
Bill & Melinda Gates Foundation INV-004709NIAID NIH HHS 1DP2AI144850-01NIAID NIH HHS DP2 AI144850NIAID NIH HHS P01 AI143575NIAID NIH HHS U19 AI162584NIH HHS P01AI143575NIH HHS R01130018NIH HHS U19AI162584
6 · The paper itself

Abstract

Cyclic AMP (cAMP) is a ubiquitous second messenger that transduces signals from cellular receptors to downstream effectors.

Indexed as

Mycobacterium tuberculosisTuberculosisCyclic AMPDrug ResistanceFatty AcidsHumansCyclic AMPFatty Acidsantibiotic resistancecAMPfatty acidsinfectious diseasemetabolismmicrobiologyM. tuberculosis

Identifiers

PMID36810158
PMCPMC9995111
OpenAlexW4321494502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.