Evidence map›Paper›PMID 36810133›Full record

ArticleeLife2023

Enteroendocrine cell lineages that differentially control feeding and gut motility.

Marito Hayashi, Judith A Kaye, Ella R Douglas, Narendra R Joshi, Fiona M Gribble, Frank Reimann, Stephen D Liberles

Open access · goldFull text read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Altered GScience advances · 2026
    Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2026
    Article
  6. Mechanisms and clinical implications of gut-brain interactions.The Journal of clinical investigation · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Incretin hormones and obesity.The Journal of physiology · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marito HayashiDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-9367-6389
Judith A KayeDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.
Ella R DouglasDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.
Narendra R JoshiDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-5030-389X
Fiona M GribbleWellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-4232-2898
Frank ReimannWellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9399-6377
Stephen D LiberlesDepartment of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, United States.ORCID 0000-0002-2177-9741
Howard Hughes Medical Institute · USUniversity of Cambridge · GB

Funding

TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
Sensory receptors of the vagus nerveDP1AT009497 · NCCIH · HARVARD MEDICAL SCHOOL · PI LIBERLES, STEPHEN DANIEL · 2016 to 2020
$5.9M
Charting Vagal Circuits Containing Glucagon-Like Peptide 1 ReceptorR01DK103703 · NIDDK · HARVARD MEDICAL SCHOOL · PI LIBERLES, STEPHEN DANIEL · 2016 to 2019
$1.5M
Instrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737k
Howard Hughes Medical InstituteHoward Hughes Medical Institute P30 NS072030Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/3NCCIH NIH HHS DP1 AT009497NIDDK NIH HHS R01 DK103703NIH HHS S10 OD028635NIH HHS T32 HL007901
6 · The paper itself

Abstract

Enteroendocrine cells are specialized sensory cells of the gut-brain axis that are sparsely distributed along the intestinal epithelium. The functions of enteroendocrine cells have classically been inferred by the gut hormones they release. However, individual enteroendocrine cells typically produce multiple, sometimes apparently opposing, gut hormones in combination, and some gut hormones are also produced elsewhere in the body. Here, we developed approaches involving intersectional genetics to enable selective access to enteroendocrine cells in vivo in mice. We targeted FlpO expression to the endogenous

Indexed as

Enteroendocrine CellsGlucagon-Like Peptide 1AnimalsCell LineageCholecystokininGastric Inhibitory PolypeptideMiceCholecystokininGastric Inhibitory PolypeptideGlucagon-Like Peptide 1appetiteenteroendocrine cellgut-brain axisintersectional geneticsmouseneurosciencesingle-cell RNA sequencing

Identifiers

PMID36810133
PMCPMC10032656
OpenAlexW4321495944

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read86
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.